{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:49:05Z","timestamp":1790804945121,"version":"4.1.0"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01GI1008C"],"award-info":[{"award-number":["01GI1008C"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The nonmotor symptom spectrum of Parkinson\u2019s disease (PD) includes progressive cognitive decline mainly in late stages of the disease. The aim of this study was to map the patterns of altered structural connectivity of patients with PD with different cognitive profiles ranging from cognitively unimpaired to PD-associated dementia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Diffusion tensor imaging and neuropsychological data from the observational multicentre LANDSCAPE study were analyzed. A total of 134 patients with PD with normal cognitive function (56 PD-N), mild cognitive impairment (67 PD-MCI), and dementia (11 PD-D) as well as 72 healthy controls were subjected to whole-brain-based fractional anisotropy mapping and covariance analysis with cognitive performance measures. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Structural data indicated subtle changes in the corpus callosum and thalamic radiation in PD-N, whereas severe white matter impairment was observed in both PD-MCI and PD-D patients including anterior and inferior fronto-occipital, uncinate, insular cortices, superior longitudinal fasciculi, corona radiata, and the body of the corpus callosum. These regional alterations were demonstrated for PD-MCI and were more pronounced in PD-D. The pattern of involved regions was significantly correlated with the Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD) total score. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> The findings in PD-N suggest impaired cross-hemispherical white matter connectivity that can apparently be compensated for. More pronounced involvement of the corpus callosum as demonstrated for PD-MCI together with affection of fronto-parieto-temporal structural connectivity seems to lead to gradual disruption of cognition-related cortico-cortical networks and to be associated with the onset of overt cognitive deficits. The increase of regional white matter damage appears to be associated with the development of PD-associated dementia. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756286419843447","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T15:13:37Z","timestamp":1558019617000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Structural brain signature of cognitive decline in Parkinson\u2019s disease: DTI-based evidence from the LANDSCAPE study"],"prefix":"10.1177","volume":"12","author":[{"given":"Martin","family":"Gorges","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Liepelt-Scarfone","sequence":"additional","affiliation":[{"name":"German Center of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rostock, Rostock, Germany"},{"name":"Division of Neurodegenerative Diseases, Department of Neurology, Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"German Centre for Neurodegenerative Diseases (DZNE) Rostock\/Greifswald, Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dodel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Philipps University Marburg, Marburg, Germany"},{"name":"Department of Neuro-Geriatrics, University Clinic, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"LANDSCAPE Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Hilker-Roggendorf","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Klinische Neurophysiologie, Klinikum Vest, Knappschaftskrankenhaus Recklinghausen, Recklinghausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Berg","sequence":"additional","affiliation":[{"name":"German Center of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, T\u00fcbingen, Germany"},{"name":"Department of Neurology, Christian Albrecht University, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Kalbe","sequence":"additional","affiliation":[{"name":"Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Baudrexel","sequence":"additional","affiliation":[{"name":"Department of Neurology, J.W. 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