{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:25:59Z","timestamp":1761920759890,"version":"3.41.2"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871080"],"award-info":[{"award-number":["81871080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy has been considered a novel central nervous system autoimmune disease characterized by relapse and responsiveness to corticosteroid with a specific GFAP-Immunoglobulin G (IgG) being noted in cerebrospinal fluid. We report the case of a 21-year-old girl presenting with dysuria and weariness, who subsequently developed blurry vision, slight dysphagia, slurred speech, and sensory abnormality. GFAP-IgG was detected in her cerebrospinal fluid. Magnetic resonance imaging using both T2-weighted and contrast-enhanced T1-weighted images revealed a rare finding of lesions distributed mainly in the entire spinal cord rather than typical brain lesions. After treating with corticosteroids, her clinical symptoms were alleviated, and the spinal cord lesion enhancement was reduced. Our observations extend the clinical spectrum of autoimmune GFAP astrocytopathy. We suggest that rare distributed lesions in the entire spinal cord in patients with autoimmune GFAP astrocytopathy cannot be ignored by neurologists. The identification of potential atypical lesions broadens the understanding of autoimmune GFAP astrocytopathy. <\/jats:p>","DOI":"10.1177\/1756286420909973","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T10:22:10Z","timestamp":1591179730000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Autoimmune glial fibrillary acidic protein astrocytopathy with lesions distributed predominantly in the entire spinal cord"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-6932","authenticated-orcid":false,"given":"Xue-Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, Jining No. 1 People\u2019s Hospital, Jining, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Tian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jining No. 1 People\u2019s Hospital, Jining, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Ming","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry, The First Affiliate Hospital of Dalian Medical University, No. 222, Zhongshan Road, Dalian, Liaoning Province 116011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-4924","authenticated-orcid":false,"given":"Hai-Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jining No. 1 People\u2019s Hospital, No. 6, Jiankang Road, Jining, Shandong Province, 272011, 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