{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:29:58Z","timestamp":1791973798679,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Although the pathogenesis of myasthenia gravis (MG) is well known, prognostic markers are not yet available. We assessed the utility of anti-acetylcholine receptor (AChR) antibody (AChR-ab) titer and concentration of C3, C4, and C5a as potential severity biomarkers in MG. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Levels of C3, C4, C5a, and AChR-ab were measured in 60 AChR-ab-positive patients with MG. Their relationship with clinical severity was analyzed using the activities of daily living (ADL) and MG composite (MGC) scales. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> AChR-ab titer correlated with severity of MG according to ADL ( p\u2009=\u20090.002) and MGC scales ( p\u2009=\u20090.001). When patients were classified according to disease duration, a statistically significant correlation between AChR-ab titer and clinical severity was only found in the subgroup of patients with fewer than 5\u2009years from symptoms onset. C5a levels showed a positive correlation with MG severity according to the ADL scale ( p\u2009=\u20090.041; \u03c4b\u2009=\u20090.18), although C5a levels were not different from the control group. <\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion:<\/jats:title><jats:p> AChR-ab titers and C5a levels could potentially be considered markers of severity in patients with MG. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756286420935697","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T13:00:04Z","timestamp":1597064404000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["C3, C5a and anti-acetylcholine receptor antibody as severity biomarkers in myasthenia gravis"],"prefix":"10.1177","volume":"13","author":[{"given":"Florencia","family":"Aguirre","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda, Divisi\u00f3n Neurolog\u00eda, Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda. Centro Argentino de Neuroinmunolog\u00eda (CADENI). Facultad de Medicina - Universidad de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analisa","family":"Manin","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda, Divisi\u00f3n Neurolog\u00eda, Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda. Centro Argentino de Neuroinmunolog\u00eda (CADENI). Facultad de Medicina - Universidad de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda, Divisi\u00f3n Neurolog\u00eda, Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda. Centro Argentino de Neuroinmunolog\u00eda (CADENI). Facultad de Medicina - Universidad de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano E.","family":"Justo","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Inmunolog\u00eda. CONICET - Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Leoni","sequence":"additional","affiliation":[{"name":"CONICET - Universidad de Buenos Aires, Instituto de Estudios de la, Inmunidad Humoral (IDEHU), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela L.","family":"Paz","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Inmunolog\u00eda. CONICET - Universidad de Buenos Aires, Instituto de Estudios de la Inmunidad Humoral (IDEHU), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-1482","authenticated-orcid":false,"given":"Andres M.","family":"Villa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Neuroinmunolog\u00eda y Electrofisiolog\u00eda, Divisi\u00f3n Neurolog\u00eda, Hospital Jos\u00e9 Mar\u00eda Ramos Mej\u00eda. Centro Argentino de Neuroinmunolog\u00eda (CADENI). Facultad de Medicina - Universidad de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"bibr1-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200004)23:4<453::AID-MUS3>3.0.CO;2-O"},{"key":"bibr2-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1054"},{"key":"bibr3-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.036"},{"key":"bibr4-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.7.601"},{"key":"bibr5-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.03.003"},{"key":"bibr6-1756286420935697","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903555943"},{"key":"bibr7-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1038\/85520"},{"key":"bibr8-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22312"},{"key":"bibr9-1756286420935697","first-page":"82","volume":"67","author":"Rodgaard A","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"bibr10-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"bibr11-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.07.006"},{"key":"bibr12-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05186-2"},{"key":"bibr13-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.4.1.43"},{"key":"bibr14-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03198.x"},{"key":"bibr15-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"key":"bibr16-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.24"},{"key":"bibr17-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.41.5.394"},{"key":"bibr18-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410100506"},{"key":"bibr19-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.5.496"},{"key":"bibr20-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23944"},{"key":"bibr21-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302705"},{"key":"bibr22-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114060"},{"key":"bibr23-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198208000-00001"},{"key":"bibr24-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb33739.x"},{"key":"bibr25-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13522"},{"key":"bibr26-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.3.266"},{"key":"bibr27-1756286420935697","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-105-26050"},{"key":"bibr28-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221129"},{"key":"bibr29-1756286420935697","first-page":"582","volume":"267","author":"Kuncl RW","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr30-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.08.002"},{"key":"bibr31-1756286420935697","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21398"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756286420935697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1756286420935697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756286420935697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T13:31:25Z","timestamp":1740922285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1756286420935697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":31,"alternative-id":["10.1177\/1756286420935697"],"URL":"https:\/\/doi.org\/10.1177\/1756286420935697","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1756286420935697"}}