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The meticulous clinical description of patients with MOG IgG antibodies (MOG-IgG) has been achieved by development and use of highly specific cell-based assays. MOG-IgG associated disorders comprise a wide spectrum of syndromes ranging from acute disseminated encephalomyelitis predominantly in children to optic neuritis or myelitis mostly in adults. In recent studies, phenotype of MOG-IgG associated disorders has further broadened with the description of cases of brainstem encephalitis, encephalitis with seizures and overlap syndromes with other types of autoimmune encephalitis. In this review, we provide an overview of current knowledge of MOG-IgG associated disorders, describe the clinical presentations identified, highlight differences from neuromyelitis optica spectrum disorders and multiple sclerosis, summarize clinical outcome and concepts of immune treatment, depict the underlying mechanisms of antibody pathogenicity and provide the methodological essentials of MOG-IgG assays. <\/jats:p>","DOI":"10.1177\/1756286420945135","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T09:25:18Z","timestamp":1596187518000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["Recent developments in MOG-IgG associated neurological disorders"],"prefix":"10.1177","volume":"13","author":[{"given":"Harald","family":"Hegen","sequence":"first","affiliation":[{"name":"Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, 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