{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:34:01Z","timestamp":1783791241460,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> We report a case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalomyelitis following vector-based vaccination against SARS-CoV-2 that mimicked bacterial meningomyelitis upon initial presentation. A 43-year-old woman who had received a first dose of ChAdOx1 nCoV-19 (Vaxzevria; Astra Zeneca, UK Limited) 9 days earlier presented with subacute sensorimotor paraparesis, urinary retention, headache, meningism, and fever. Clinical findings and cerebrospinal fluid (CSF) features were highly suggestive of bacterial infection; however, despite receiving broad anti-infective treatment alongside with high-dose glucocorticoids, symptoms deteriorated. Imaging findings and the detection of immunoglobulin G against MOG substantiated diagnosis of an anti-MOG associated disorder. Treatment with high-dose intravenous (IV) methylprednisolone and plasma exchange resulted in substantial clinical improvement, which sustained under monthly regimen of IV Tocilizumab at 3-month follow-up. Awareness of this post-vaccinal presentation of a rare autoimmune disorder is important to not miss potential treatment options. <\/jats:p>","DOI":"10.1177\/17562864211070684","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T09:01:06Z","timestamp":1642582866000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["MOG antibody\u2013associated encephalomyelitis mimicking bacterial meningomyelitis following ChAdOx1 nCoV-19 vaccination: a case report"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8742-0694","authenticated-orcid":false,"given":"Jordi K\u00fchne","family":"Escol\u00e0","sequence":"first","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Deuschl","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Junker","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Dusse","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-9317","authenticated-orcid":false,"given":"Refik","family":"Pul","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kleinschnitz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"K\u00f6hrmann","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8837-9489","authenticated-orcid":false,"given":"Benedikt","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"bibr1-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8596-7"},{"key":"bibr2-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3196"},{"key":"bibr3-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0719-z"},{"key":"bibr4-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308346"},{"key":"bibr5-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"key":"bibr6-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102857"},{"key":"bibr7-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001049"},{"key":"bibr8-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102474"},{"key":"bibr9-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05427-4"},{"key":"bibr10-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10647-x."},{"key":"bibr11-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01824-2"},{"key":"bibr12-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-008-0002-x"},{"key":"bibr13-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.01.050"},{"key":"bibr14-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09440-8"},{"key":"bibr15-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519837705"},{"key":"bibr16-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02140-1"},{"key":"bibr17-17562864211070684","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2018-104"},{"key":"bibr18-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5857"},{"key":"bibr19-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12898"},{"key":"bibr20-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005560"},{"key":"bibr21-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx276"},{"key":"bibr22-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007312"},{"key":"bibr23-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.11.012"},{"key":"bibr24-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102483"},{"key":"bibr25-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25805"},{"key":"bibr26-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab223"},{"key":"bibr27-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102696"},{"key":"bibr28-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211003476"},{"key":"bibr29-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327200."},{"key":"bibr30-17562864211070684","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103189"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864211070684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864211070684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864211070684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T17:11:41Z","timestamp":1741021901000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864211070684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"alternative-id":["10.1177\/17562864211070684"],"URL":"https:\/\/doi.org\/10.1177\/17562864211070684","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"17562864211070684"}}