{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:55:55Z","timestamp":1790564155164,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1181 \u2013 261193037 project B07"],"award-info":[{"award-number":["SFB1181 \u2013 261193037 project B07"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> The impact of the gut and its microbiota are increasingly appreciated in health and disease. Short-chain fatty acids (SCFAs) are among the main metabolites synthesized from bacterial fermentation. Recently, we showed the anti-inflammatory and potentially neuroprotective effect of propionic acid (PA) in multiple sclerosis (MS). Osteoporosis is one of the most common co-morbidities for MS patients with limited therapeutic options available. Osteoporosis is closely linked to an imbalance of cells of the immune system and an immune-mediated impact on bone structure via the gut has been shown. Interestingly, intake of SCFA leads to bone mass increase and concomitant reduction of inflammation-induced bone loss in mice. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p> To determine the impact of PA supplementation on markers of bone metabolism in MS patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We investigated the influence of 14\u2009days supplementation with PA on bone metabolism in 20 MS patients. To this end, \u03b2-CrossLaps and osteocalcin, established markers of bone metabolism, were measured in serum before and after PA intake and correlated with phenotypic and functional immunodata. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Supplementation with PA induced a significant increase in serum levels of osteocalcin, a surrogate marker for bone formation. Levels of \u03b2-CrossLaps, a marker for bone resorption, were significantly decreased after therapy. Regulatory T-cell (Treg) numbers and suppressive capacity positively correlated with serum levels of osteocalcin while Th17 cell numbers showed an inverse correlation. Our findings are in line with animal studies showing that SCFA induced increased bone formation and reduced bone resorption. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In addition to its immune regulatory, disease-modifying effect on MS disease course, supplementation with PA beneficially influences serum levels of \u03b2-CrossLaps and osteocalcin and may thus also protect against osteoporosis, a common co-morbidity in MS. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562864221103935","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T12:13:58Z","timestamp":1655813638000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Propionic acid beneficially modifies osteoporosis biomarkers in patients with multiple sclerosis"],"prefix":"10.1177","volume":"15","author":[{"given":"Alexander","family":"Duscha","sequence":"first","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum Magdeburg A.\u00f6.R., Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hegelmaier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum Magdeburg A.\u00f6.R., Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"D\u00fcrholz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinik Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Desel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum Magdeburg A.\u00f6.R., Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital Bochum, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario M.","family":"Zaiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-N\u00fcrnberg (FAU) and Universit\u00e4tsklinik Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"Haghikia","sequence":"additional","affiliation":[{"name":"Chair and Head of Department, Department of Neurology, Universit\u00e4tsklinikum Magdeburg A.\u00f6.R., Otto von Guericke University Magdeburg, Leipziger Stra\u00dfe 44, 39120 Magdeburg, 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