{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:15:53Z","timestamp":1791224153044,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Herein, we report a case of alopecia universalis and transient accommodation spasm presented after alemtuzumab administration in a patient previously treated with fingolimod. To the best of our knowledge, this is the first report of accommodation spasm as an acute adverse effect of alemtuzumab. Treatment with alemtuzumab in relapsing-remitting multiple sclerosis has been identified as a risk factor for developing secondary autoimmunity within the follow-up period (peak 18\u201336 months from the first infusion) such as thyroid disorders. This case highlights the need for postmarketing surveillance and the significance of reporting rare side effects related to alemtuzumab; its high efficacy should be weighted with potentially severe adverse events when making a therapeutic decision. Further studies in larger cohorts are needed to elucidate pathomechanisms of alemtuzumab. <\/jats:p>","DOI":"10.1177\/17562864221127476","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T06:04:25Z","timestamp":1665295465000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Alemtuzumab-induced alopecia universalis and transient accommodation spasm in a patient with multiple sclerosis"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-3327","authenticated-orcid":false,"given":"Dimitrios","family":"Tzanetakos","sequence":"first","affiliation":[{"name":"2nd Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 1 Rimini Street, 12462 Athens, Greece"},{"name":"Multiple Sclerosis & Demyelinating Diseases Unit, 1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-7941","authenticated-orcid":false,"given":"Marianthi","family":"Breza","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Queen Square Institute of Neurology, UCL, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Tzartos","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Bontzos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u2018Korgialenio-Benakio\u2019, Red Cross General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-7216","authenticated-orcid":false,"given":"Aigli G.","family":"Vakrakou","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis & Demyelinating Diseases Unit, 1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Dermentzoglou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u2018Korgialenio-Benakio\u2019, Red Cross General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Gkizis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u2018Korgialenio-Benakio\u2019, Red Cross General Hospital, Athens, 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