{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:28:55Z","timestamp":1792114135778,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> There are limited data on the impact of myasthenia gravis (MG) on real-world healthcare resource use (HCRU) and patient burden in the United States. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> This study aims to assess HCRU in patients with MG using data from a US health claims database. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> A retrospective, database study of adult patients newly diagnosed with MG, using the IBM<jats:sup>\u00ae<\/jats:sup> MarketScan<jats:sup>\u00ae<\/jats:sup> Commercial Claims and Encounters and Medicare supplemental health insurance claims database. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Patients with \u2a7e2 MG International Classification of Disease diagnosis codes \u2a7e3\u2009months apart were followed from the date of their first MG diagnosis record or start of treatment. HCRU and use of immunoglobulins and plasma exchange during follow-up was assessed, as well as comorbidities, hospitalizations, emergency room (ER) visits, intensive care unit (ICU) admissions, and specialist visits per year after diagnosis, and compared with age- and sex-matched non-MG controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> During 2010\u20132019, 7194 patients were followed for up to 10\u2009years (median\u2009=\u20092.3\u2009years). During follow-up, patients with MG were 2.6-fold more likely than controls to be hospitalized, and 4.5-fold more likely to be admitted to an ICU. Risk and numbers of ER admission, hospitalization, and ICU visits were the highest in the 12\u2009months post-diagnosis of MG and were consistently higher than controls during follow-up. MG was the main cause for most hospitalizations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Patients with MG have higher HCRU, compared with the age- and sex-matched non-MG controls. The early years after MG diagnosis are a period of particularly high healthcare burden, with many patients requiring hospitalization and ICU care to manage serious exacerbations. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562864221150327","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T12:45:11Z","timestamp":1674564311000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Healthcare resource use in myasthenia gravis: a US health claims analysis"],"prefix":"10.1177","volume":"16","author":[{"given":"Milada","family":"Mahic","sequence":"first","affiliation":[{"name":"UCB Pharma, Slough, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bozorg","sequence":"additional","affiliation":[{"name":"UCB Pharma, Morrisville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rudnik","sequence":"additional","affiliation":[{"name":"UCB Pharma, Warszawa, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Zaremba","sequence":"additional","affiliation":[{"name":"UCB Pharma, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-9243","authenticated-orcid":false,"given":"Anna","family":"Scowcroft","sequence":"additional","affiliation":[{"name":"UCB Pharma, 208 Bath Road, Slough SL1 3WE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"bibr1-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-44"},{"key":"bibr2-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8045-z"},{"key":"bibr3-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13522"},{"key":"bibr4-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002790"},{"key":"bibr5-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14547"},{"key":"bibr6-17562864221150327","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00538"},{"key":"bibr7-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22327"},{"key":"bibr8-17562864221150327","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2019.15.3.376"},{"key":"bibr9-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26114."},{"key":"bibr10-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-020-00912-8"},{"key":"bibr11-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22212"},{"key":"bibr12-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200212000-00009"},{"key":"bibr13-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"bibr14-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a41211"},{"key":"bibr15-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03850.x"},{"key":"bibr16-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008903"},{"key":"bibr17-17562864221150327","volume":"2021","author":"Mahic M","year":"2021","journal-title":"Am Assoc Neuromusc Electrodiagn Med"},{"key":"bibr18-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00703-2018"},{"key":"bibr19-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-30"},{"key":"bibr20-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24213"},{"key":"bibr21-17562864221150327","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2009.035"},{"key":"bibr22-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000858"},{"key":"bibr23-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011124"},{"key":"bibr24-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004341"},{"key":"bibr25-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001116"},{"key":"bibr26-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.793"},{"key":"bibr27-17562864221150327","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0079-y"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864221150327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864221150327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864221150327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:02:18Z","timestamp":1740985338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864221150327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":27,"alternative-id":["10.1177\/17562864221150327"],"URL":"https:\/\/doi.org\/10.1177\/17562864221150327","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17562864221150327"}}