{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:01:05Z","timestamp":1774972865612,"version":"3.50.1"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Granulomatosis or eosinophilic granulomatosis with polyangiitis (GPA\/EGPA) can affect multiple organs resulting in heterogeneous symptoms and phenotypes. Pituitary gland dysfunction rarely occurs in GPA (1\u20133%) and even less in EGPA (two case reports). Here, we report a case of a 51-year-old female patient with a four-year history of EGPA who presented with new polydipsia and polyuria. Laboratory testing and magnetic resonance imaging (MRI) confirmed pituitary gland dysfunction caused by a hypophysitis. Therapeutic adjustment with a switch from dupilumab to mepolizumab resulted in a decrease in clinical symptoms, inflammation in MRI, and normalization of C-reactive protein in serum. This case underlines hypophysitis as a rare organ involvement also in EGPA. Moreover, this case demonstrates the responsiveness of neuroinflammatory manifestations to the recently approved anti-interleukin-5 monoclonal antibody mepolizumab as a new potential treatment option. <\/jats:p>","DOI":"10.1177\/17562864231182519","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T06:22:26Z","timestamp":1687587746000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-4121","authenticated-orcid":false,"given":"Jessy","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"Experimental and Clinical Research Center, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thula","family":"Walter-Rittel","sequence":"additional","affiliation":[{"name":"Department of Radiology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia","family":"Ziagaki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Siffrin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Experimental Neurology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Clinician Scientist Program, Berlin Institute of Health, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"bibr1-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000748"},{"key":"bibr2-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-017-0811-0"},{"key":"bibr3-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1962"},{"key":"bibr4-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04735-7"},{"key":"bibr5-17562864231182519","first-page":"17","volume":"135","author":"Vom\u00e1cka Z","year":"1993","journal-title":"Acta Univ Palacki Olomuc Fac Med"},{"key":"bibr6-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2016-134148"},{"key":"bibr7-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"bibr8-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60988-X"},{"key":"bibr9-17562864231182519","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702079"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864231182519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864231182519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864231182519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T02:49:11Z","timestamp":1740797351000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864231182519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":9,"alternative-id":["10.1177\/17562864231182519"],"URL":"https:\/\/doi.org\/10.1177\/17562864231182519","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17562864231182519"}}