{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:16:25Z","timestamp":1765041385105,"version":"3.41.2"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> IgG4-related disease (IgG4-RD) is an emerging immune-mediated chronic fibrotic disease characterized by tumour-like mass formation. Reports of brain parenchymal involvement in IgG4-RD are rare and complete treatment-related remission of lesions has never been reported. Here, we present a woman in her mid-50s who developed headache and seizures. Brain magnetic resonance imaging revealed frontal bilateral pachymeningitis and a left frontal lobe parenchymal lesion, and pathologic findings were consistent with an IgG4-RD central nervous system manifestation. She had a history of tumour-like growth around the right optic nerve, orbital and maxillary cavities treated successfully with corticosteroids 28\u2009years ago, and was receiving infliximab as a maintenance therapy for uveitis for the last 14\u2009years. After initial high-dose corticosteroid treatment, the patient was treated with rituximab, and after 3 months, the patient presented with complete remission of IgG4-RD lesions and associated symptoms. This case illustrates the chronic, decades-spanning nature of IgG4-RD, and a complete response to rituximab even with intracerebral mass lesions that had emerged despite the use of infliximab, a therapy previously reported successful in IgG4-RD. <\/jats:p>","DOI":"10.1177\/17562864231186091","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T11:39:22Z","timestamp":1689680362000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Complete remission of central nervous system manifestations of IgG4-related disease with rituximab \u2013 a case report"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-7338","authenticated-orcid":false,"given":"Aleksi J.","family":"Sihvonen","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurocenter, Helsinki University Central Hospital, Haartmaninkatu 4, P.O. Box 340, 00029 Helsinki, Finland"},{"name":"Clinical Neurosciences, Neurology, University of Helsinki and Brain Center, Helsinki University Hospital, Helsinki, Finland"},{"name":"Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland"},{"name":"Centre of Excellence in Music, Mind, Body and Brain, University of Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sini M.","family":"Laakso","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Neurology, University of Helsinki and Brain Center, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Tynninen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Saaren-Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervi","family":"L\u00f6fberg","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Neurology, University of Helsinki and Brain Center, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"bibr1-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0500-7"},{"key":"bibr2-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"bibr3-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.054"},{"key":"bibr4-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181abdfc2"},{"key":"bibr5-17562864231186091","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3147"},{"key":"bibr6-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1012-1"},{"key":"bibr7-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.40"},{"key":"bibr8-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00669-0"},{"key":"bibr9-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.243"},{"key":"bibr10-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117420"},{"key":"bibr11-17562864231186091","doi-asserted-by":"publisher","DOI":"10.3171\/2011.7.JNS1166"},{"key":"bibr12-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3855"},{"key":"bibr13-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000041"},{"key":"bibr14-17562864231186091","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000625"},{"key":"bibr15-17562864231186091","volume":"5","author":"Katz G","year":"2021","journal-title":"Rheumatol Adv Pract"},{"key":"bibr16-17562864231186091","doi-asserted-by":"publisher","DOI":"10.4103\/aian.aian_457_22"},{"key":"bibr17-17562864231186091","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202113953"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864231186091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864231186091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864231186091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T17:35:51Z","timestamp":1740764151000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864231186091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":17,"alternative-id":["10.1177\/17562864231186091"],"URL":"https:\/\/doi.org\/10.1177\/17562864231186091","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"type":"print","value":"1756-2864"},{"type":"electronic","value":"1756-2864"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17562864231186091"}}