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A potential therapeutic target that could offer favorable outcomes in stroke is the mammalian target of rapamycin (mTOR) pathway. mTOR is a serine\/threonine kinase that composes two protein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), and is regulated by other proteins such as the tuberous sclerosis complex. Through a significant number of signaling pathways, the mTOR pathway can modulate the processes of post-ischemic inflammation and autophagy, both of which play an integral part in the pathophysiological cascade of stroke. Promoting or inhibiting such processes under ischemic conditions can lead to apoptosis or instead sustained viability of neurons. The purpose of this review is to examine the pathophysiological role of mTOR in acute ischemic stroke, while highlighting promising neuroprotective agents such as hamartin for therapeutic modulation of this pathway. The therapeutic potential of mTOR is also discussed, with emphasis on implicated molecules and pathway steps that warrant further elucidation in order for their neuroprotective properties to be efficiently tested in future clinical trials. <\/jats:p>","DOI":"10.1177\/17562864231187770","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T12:08:05Z","timestamp":1691582885000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["mTOR pathway \u2013 a potential therapeutic target in stroke"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-3053","authenticated-orcid":false,"given":"Konstantinos","family":"Melanis","sequence":"first","affiliation":[{"name":"Second Department of Neurology, School of Medicine and \u2018Attikon\u2019 University Hospital, National and Kapodistrian University of Athens, Rimini 1 Chaidari, Athens 12462, Greece"},{"name":"Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-6627","authenticated-orcid":false,"given":"Maria-Ioanna","family":"Stefanou","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, School of Medicine and \u2018Attikon\u2019 University Hospital, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos M.","family":"Themistoklis","sequence":"additional","affiliation":[{"name":"Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece"},{"name":"Department of Neurosurgery, \u2018Korgialenio, Benakio, H.R.C\u2019. 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