{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T11:52:39Z","timestamp":1794397959253,"version":"4.9.0"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2022ZYD0051 and 2022ZDZX0023"],"award-info":[{"award-number":["2022ZYD0051 and 2022ZDZX0023"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501203"],"award-info":[{"award-number":["2021YFC2501203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The calcium channel has been considered to have great potential as a drug target for neuroprotective therapy in Parkinson\u2019s disease (PD), but previous studies yielded inconsistent results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to conduct a systematic review and meta-analysis to assess the relationship between using calcium channel blockers (CCBs) and the risk and progression of PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources and methods:<\/jats:title>\n                    <jats:p>The terms such as \u2018Parkinson\u2019s disease\u2019, \u2018PD\u2019, \u2018calcium channel blockers\u2019, and \u2018CCB\u2019 were used to search the literature published before 1 May 2023 in English databases, including PubMed, Embase, and Cochrane Library, for studies on CCB and PD. Data analysis was performed using Review Manager 5.3 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 190 works of literature were preliminarily retrieved, and 177 works of literature were excluded by eliminating duplicates, reading abstracts, and reading full texts. A total of nine studies were finally included in the meta-analysis of the CCB and the risk of PD, and five studies were included in the systematic review of the CCB and the progression of PD. A total of 2,961,695 participants were included in the meta-analysis. The random-effects model was used for analysis due to significant heterogeneity. The main results of the meta-analysis showed that the use of CCB could reduce the risk of PD (relative risk 0.78, 95% confidence interval 0.62\u20130.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CCB use was associated with a significantly reduced risk of PD. Whether CCB use has a disease-modifying effect on PD needs further study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>PROSPERO: CRD42024508242.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864241252713","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T01:23:13Z","timestamp":1716168193000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Calcium channel blockers and Parkinson\u2019s disease: a systematic review and meta-analysis"],"prefix":"10.1177","volume":"17","author":[{"given":"Junyu","family":"Lin","sequence":"first","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejiang","family":"Pang","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwei","family":"Ou","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-1151","authenticated-orcid":false,"given":"Huifang","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University, Guoxue Road No. 37, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"key":"bibr1-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00207-5"},{"key":"bibr2-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00030-2"},{"key":"bibr3-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.028738"},{"key":"bibr4-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010818-021214"},{"key":"bibr5-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117412"},{"key":"bibr6-17562864241252713","volume":"9","author":"Lee Y-C","year":"2014","journal-title":"PLoS One"},{"key":"bibr7-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr362"},{"key":"bibr8-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21937"},{"key":"bibr9-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000303818.38960.44"},{"key":"bibr10-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23191"},{"key":"bibr11-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1159\/000235641"},{"key":"bibr12-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.08.011"},{"key":"bibr13-17562864241252713","doi-asserted-by":"publisher","DOI":"10.5414\/CP203559"},{"key":"bibr14-17562864241252713","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29367"},{"key":"bibr15-17562864241252713","doi-asserted-by":"crossref","unstructured":"The Parkinson Study Group STEADY-PD III Investigators. 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