{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:21:52Z","timestamp":1769854912168,"version":"3.49.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Characterizing Cladribine tablets prescription pattern in daily clinical practice is crucial for optimizing multiple sclerosis (MS) treatment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To describe efficacy, safety profile and new disease-modifying therapy (DMT) prescriptions following Cladribine treatment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> Independent retrospective cohort study in patients followed at six Italian MS centres. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Patients diagnosed with relapsing MS (RMS) according to 2017 McDonald criteria, who initiated Cladribine between January 2019 and May 2023, were included. A generalized linear regression model was built for the outcome DMT after Cladribine course. Heatmaps were generated based on weighted pivot tables to visualize the proportion of patients requiring DMT post-Cladribine. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total cohort of 352 patients was enrolled, 134 na\u00efve to any DMT, 218 switchers from other DMTs. The last DMT was an injectable first-line DMT for 48 (22%) patients, oral first-line DMT for 141 (64.7%) patients, SP1 inhibitor-Fingolimod for 23 (10.6%) patients, and Natalizumab for 6 (2.7%) patients. Overall, Cladribine was efficacious and well tolerated, 12% of patients required a new DMT prescription after a median time of 24 months. The regression model revealed that patients aged &gt;40\u2009years at Cladribine prescription had a 16% decrease in likelihood of receiving a new DMT. Heatmaps showed patients previously on Fingolimod had a lower rate (72.2%) of being free from therapy after Cladribine. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In our multicentric real-world Italian study, Cladribine therapy is generally effective during the investigated follow-up period. Understanding key characteristics of patients responding best to Cladribine can help tailor therapeutic strategies for optimal outcomes. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562864241304212","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:52:51Z","timestamp":1736344371000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying Cladribine prescription pattern in MS: an Italian multicentre study"],"prefix":"10.1177","volume":"18","author":[{"given":"Aurora","family":"Zangh\u00ec","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Fantozzi","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed, Pozzilli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Foschi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Multiple Sclerosis Center \u2013 Neurology Unit, S. Maria delle Croci Hospital, Azienda USL Romagna, Ravenna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-6752","authenticated-orcid":false,"given":"Elisabetta","family":"Signoriello","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre, II Division of Neurology, Department of Clinical and Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Inglese","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child Health (DINOGMI), University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Lus","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre, II Division of Neurology, Department of Clinical and Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-8545","authenticated-orcid":false,"given":"Diego","family":"Centonze","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed, Pozzilli, Italy"},{"name":"Department of System Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Surcinelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Multiple Sclerosis Center \u2013 Neurology Unit, S. Maria delle Croci Hospital, Azienda USL Romagna, Ravenna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Sirito","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child Health (DINOGMI), University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bonavita","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Avolio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-9057","authenticated-orcid":false,"given":"Emanuele","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, Foggia 71122, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"bibr1-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01473-3"},{"key":"bibr2-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11193-w"},{"key":"bibr3-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211010294"},{"key":"bibr4-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01865-w"},{"key":"bibr5-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211049392"},{"key":"bibr6-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00364-6"},{"key":"bibr7-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200048"},{"key":"bibr8-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1792885"},{"key":"bibr9-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"bibr10-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww173"},{"key":"bibr11-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1177\/17562864231183221"},{"key":"bibr12-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1177\/17562864231200627"},{"key":"bibr13-17562864241304212","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X21666230322140711"},{"key":"bibr14-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11700-7"},{"key":"bibr15-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00339-7"},{"key":"bibr16-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00394-0"},{"key":"bibr17-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00243-6"},{"key":"bibr18-17562864241304212","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.763433"},{"key":"bibr19-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103490"},{"key":"bibr20-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-024-00603-y"},{"key":"bibr21-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1177\/1756286419887596"},{"key":"bibr22-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0461-6"},{"key":"bibr23-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101938"},{"key":"bibr24-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103812"},{"key":"bibr25-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105134"},{"key":"bibr26-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.09.041"},{"key":"bibr27-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.05.003"},{"key":"bibr28-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.11.021"},{"key":"bibr29-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518754364"},{"key":"bibr30-17562864241304212","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13745"},{"key":"bibr31-17562864241304212","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.676095"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864241304212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864241304212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864241304212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T09:10:50Z","timestamp":1740906650000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864241304212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":31,"alternative-id":["10.1177\/17562864241304212"],"URL":"https:\/\/doi.org\/10.1177\/17562864241304212","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"17562864241304212"}}