{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:00:49Z","timestamp":1791414049257,"version":"4.3.3"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62171299"],"award-info":[{"award-number":["62171299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC0907700"],"award-info":[{"award-number":["2017YFC0907700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Very-late-onset myasthenia gravis (VLOMG) refers to myasthenia gravis (MG) with onset at age 65 or older. Current research on VLOMG prognosis remains limited, especially regarding factors influencing outcomes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To identify the clinical factors that affect the short- and long-term prognosis of MG patients with an onset age \u2a7e65\u2009years. <\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p> This was a single-center, retrospective cohort study of AChR-ab positive VLOMG patients, classified into two subgroups based on age of onset: sub-very-late-onset MG (S-VLOMG, onset age \u2a7e65 and &lt;75\u2009years), and super-late-onset MG (SLOMG, onset age \u2a7e75\u2009years). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 93 patients were included, including 75 in the S-VLOMG group and 18 in the SLOMG group. Clinical, therapeutic, and prognosis data were reviewed, and the Cox regression model was used to identify factors influencing short- and long-term prognosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Patient characteristics were well balanced between the groups. Overall, 49.5% of patients achieved minimal symptom expression (MSE) within 6\u2009months and 86% within 24\u2009months. There was no significant difference between the groups in the proportion achieving MSE at 6\u2009months ( p\u2009=\u20090.635) or 24\u2009months ( p\u2009=\u20090.714). The median time to achieve MSE was also comparable between the S-VLOMG and SLOMG groups (199.0\u2009days vs 280.5\u2009days, p\u2009=\u20090.463). Low baseline MG-ADL score and steroid therapy were associated with better short-term prognosis ( p\u2009=\u20090.007 and p\u2009=\u20090.002, respectively). For long-term prognosis, baseline bulbar and limb involvement, time to treatment initiation, and use of immunosuppressants were significant factors ( p\u2009=\u20090.025, p\u2009=\u20090.004, p\u2009=\u20090.025, and p\u2009&lt;\u20090.0001, respectively). There were no significant differences in side effects or drug withdrawal rates between two groups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This study demonstrated that AChR-ab positive VLOMG patients have a favorable prognosis and responded well to medication, with age and comorbidities showing no significant impact. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562864241309793","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:57:56Z","timestamp":1736344676000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Short-term and long-term prognoses in AChR-Ab positive very-late-onset myasthenia gravis patients"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4616-2861","authenticated-orcid":false,"given":"Nairong","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurology, 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