{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:14:10Z","timestamp":1767676450343,"version":"3.48.0"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","award":["Data mining and analysis were finalized thanks to"],"award-info":[{"award-number":["Data mining and analysis were finalized thanks to"]}],"id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Ozanimod is a new-generation sphingosine-1-phosphate (S1P) modulator, approved for the treatment of multiple sclerosis (MS), offering higher selectivity for S1P receptor 1 and 5 (SPR1-5), minimizing potential safety concerns related to S1P3 receptor activation, compared to fingolimod.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to compare the adherence and persistence on treatment in MS patients switched to ozanimod from fingolimod for safety reasons (mainly lymphopenia or liver enzymes increase).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively recruited patients treated with fingolimod who switched to ozanimod for safety reasons, with at least 12\u2009months of follow-up. We collected demographic, clinical, biochemistry, and safety data during fingolimod and after switching to ozanimod to evaluate (1) lymphocytes and liver enzymes dynamics, (2) persistence on ozanimod over 6\u2009months, (3) proportion of patients with no adverse events (NADE) on ozanimod and no evidence of disease activity (NEDA-3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We recruited 60 relapsing\u2013remitting MS patients (mean age of 42\u2009\u00b1\u20097.9\u2009years) who were treated with fingolimod for an average of 5.7\u2009years (61.6% female) and switched to ozanimod due to lymphopenia (70%) or hypertransaminasemia (21.6%). A total of 58\/60 (96%) patients persisted on treatment with ozanimod for a mean of 1.50\u2009\u00b1\u20090.49\u2009years; mean lymphocyte count increased from 0.39 to 0.56 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.025) in patients who switched due to lymphopenia; hypertransaminasemia decreased from 21.6% in fingolimod to 9.3% in ozanimod. NADE was recorded in 93% patients during ozanimod treatment and NEDA-3 in 88.3% of patients after 1\u2009year. Overall, patients with complete control of disease (NEDA) in the absence of adverse events (NADE) were 83.7% (NEDA3\/NADE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion:<\/jats:title>\n                    <jats:p>Our findings suggest that switching from fingolimod to ozanimod may mitigate lymphopenia or hypertransaminasemia and ameliorate effectiveness on disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864251328191","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T06:23:08Z","timestamp":1752128588000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Switch from fingolimod to ozanimod for safety or intolerance reasons"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-6752","authenticated-orcid":false,"given":"Elisabetta","family":"Signoriello","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Center, Second Division of Neurology, Department of Surgical and Medical Sciences, Neurological, Metabolic and Aging, University of Campania Luigi Vanvitelli, Via Pansini 5, Caserta, Naples 81100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Romano","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Second Division of Neurology, Department of Surgical and Medical Sciences, Neurological, Metabolic and Aging, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-7155","authenticated-orcid":false,"given":"Matteo","family":"Foschi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Multiple Sclerosis Center\u2014Neurology Unit, S. Maria delle Croci Hospital of Ravenna, Ravenna, Italy"},{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Zangh\u00ec","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-9057","authenticated-orcid":false,"given":"Emanuele","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Fantozzi","sequence":"additional","affiliation":[{"name":"Department of Neurology, IRCCS Neuromed, Pozzilli, Isernia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-8545","authenticated-orcid":false,"given":"Diego","family":"Centonze","sequence":"additional","affiliation":[{"name":"Department of Neurology, IRCCS Neuromed, Pozzilli, Isernia, Italy"},{"name":"Department of Systems Medicine, Tor Vergata University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Lus","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Second Division of Neurology, Department of Surgical and Medical Sciences, Neurological, Metabolic and Aging, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000560"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","unstructured":"Sica F Centonze D Buttari F. 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Neurol Ther 2019; 8(2): 231\u2013240.","DOI":"10.1007\/s40120-019-00162-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1540592"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30238-8"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30239-X"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01431-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517694089"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-023-00549-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221102584"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105135"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2019-0169"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864251328191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864251328191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864251328191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:04:41Z","timestamp":1767675881000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864251328191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":12,"alternative-id":["10.1177\/17562864251328191"],"URL":"https:\/\/doi.org\/10.1177\/17562864251328191","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"type":"print","value":"1756-2864"},{"type":"electronic","value":"1756-2864"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"article-number":"17562864251328191"}}