{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:59:57Z","timestamp":1791568797282,"version":"4.3.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016650","name":"Rare Diseases Clinical Research Network","doi-asserted-by":"publisher","award":["NIH U54 NS115054"],"award-info":[{"award-number":["NIH U54 NS115054"]}],"id":[{"id":"10.13039\/100016650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2019-12368727"],"award-info":[{"award-number":["GR-2019-12368727"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2025,11]]},"abstract":"\n Background:<\/jats:title>\n Standard management of generalized myasthenia gravis associated with anti-acetylcholine receptor autoantibodies (AChR-gMG) includes corticosteroids and nonsteroidal immunosuppressants. Complement inhibitors (CI) represent a more tailored therapeutic strategy. Real-world data on the steroid-sparing efficacy of CI remain limited.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To investigate the steroid-sparing efficacy of CI in AChR-gMG.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n We identified 69 AChR-gMG patients on corticosteroids treated with azathioprine (AZA), mycophenolate mofetil (MMF), or CI.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Steroid tapering was assessed by comparing corticosteroid dosage at several time-points to baseline.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Steroids reductions were statistically significant for all therapies at every time point compared to baseline (all\n p<\/jats:italic>\n \u2009<\u20090.001). Pairwise comparisons using the Mann\u2013Whitney\n U<\/jats:italic>\n test revealed significant differences between CI and MMF at 3\u2009months (\n p<\/jats:italic>\n \u2009=\u20090.0372), 6\u2009months (\n p<\/jats:italic>\n \u2009=\u20090.0193), and 9\u2009months (\n p<\/jats:italic>\n \u2009=\u20090.0321) and between CI and AZA at 6\u2009months (\n p<\/jats:italic>\n \u2009=\u20090.0415).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n CI rapidly and effectively reduced corticosteroid dosage in most AChR-gMG patients, suggesting their potential role as steroid-sparing therapeutic options.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/17562864251332037","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T02:09:23Z","timestamp":1748657363000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Complement inhibitor therapy as a steroid-sparing strategy in generalized myasthenia gravis"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4982-1662","authenticated-orcid":false,"given":"Sofia","family":"Marini","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Falso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Habetswallner","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 Cattolica del Sacro Cuore, L.go F. Vito, 1 00168 Rome, Italy"},{"name":"Neurology Unit, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, L.go F. Vito, 1 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0079-y"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27832"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.011"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756285617749134"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092163"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.933296"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.5407"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.28077"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb51321.x"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00916-w"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30369-1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11699-x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011124"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27656"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen3.12716"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12569-w"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12588-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1378080"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00028-0"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864251332037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864251332037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864251332037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:05:53Z","timestamp":1767675953000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864251332037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":20,"alternative-id":["10.1177\/17562864251332037"],"URL":"https:\/\/doi.org\/10.1177\/17562864251332037","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"article-number":"17562864251332037"}}