{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:42:27Z","timestamp":1789753347614,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-RHUS-0012"],"award-info":[{"award-number":["ANR-18-RHUS-0012"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anti-Yo antibodies, which target the onconeural antigen cerebellar degeneration-related 2-like (CDR2L), have been only sporadically reported in patients with post-immune checkpoint inhibitor (post-ICI) neurological syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To analyze the clinical and tumor features of patients with post-ICI anti-Yo neurological syndromes identified in a national reference center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All patients with post-ICI neurological syndromes and anti-Yo antibody positivity confirmed in a national reference center (2019\u20132024) were included. Comparative genomic hybridization array, immunohistochemistry against CDR2L, and analysis of Yo immunoreactivity using biotinylated anti-Yo sera were performed on the available tumor samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the five patients (4\/5 female, median age 61\u2009years) included, the neurological syndrome occurred after a median of 2 cycles of PD1 inhibitor. Four patients developed a rapidly progressive cerebellar syndrome (RPCS), while one presented with myelitis. All cases were severe (modified Rankin scale score 4\u20135) and did not improve with treatment. Cancer types were lung adenocarcinoma (2\/5), endometrial serous carcinoma (2\/5), and ovarian clear cell carcinoma (1\/5). Anti-Yo antibodies were retrospectively detected before ICI initiation in one patient with RPCS and an ovarian tumor. This tumor showed a gain in the\n                      <jats:italic toggle=\"yes\">CDR2L<\/jats:italic>\n                      locus, CDR2L overexpression, and Yo immunoreactivity with biotinylated anti-Yo sera, similar to ovarian tumors from patients with spontaneous anti-Yo paraneoplastic neurological syndrome. By contrast, CDR2L was not overexpressed in the lung tumor from one patient with myelitis, which nevertheless had a strong immunoreactivity with anti-Yo sera, absent in the control lung tumor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Post-ICI anti-Yo neurological syndromes may occur with atypical cancer associations, but mostly manifest with a RCPS indistinguishable from spontaneous anti-Yo paraneoplastic neurological syndromes, suggesting a similar immune-mediated attack on the cerebellum. The CDR2L antigen overexpression and the pre-ICI anti-Yo antibody positivity in the patient with ovarian cancer suggest that the ICI boosted a pre-formed, tumor-driven anti-Yo autoimmunity. Further studies are needed to clarify whether this mechanism applies to all patients and if other types of tumor alterations and\/or immune dysfunctions could be involved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864251377559","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:36:39Z","timestamp":1761539799000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and tumor features of patients with immune checkpoint inhibitor-related neurological disorders and anti-Yo antibodies"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-0185","authenticated-orcid":false,"given":"Antonio","family":"Farina","sequence":"first","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Peter","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolwenn","family":"Billet","sequence":"additional","affiliation":[{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"},{"name":"Department of Neuropathology, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9236-2428","authenticated-orcid":false,"given":"Macarena","family":"Villagr\u00e1n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Rogemond","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3202-5489","authenticated-orcid":false,"given":"Celeste","family":"Nicola","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Treilleux","sequence":"additional","affiliation":[{"name":"Department of Biopathology, Centre L\u00e9on B\u00e9rard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Duy","family":"Do","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Benaiteau","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Picard","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Meyronet","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pissaloux","sequence":"additional","affiliation":[{"name":"Cancer Genomics Platform, Department of Translational Research, Centre L\u00e9on B\u00e9rard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Villard","sequence":"additional","affiliation":[{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-4549","authenticated-orcid":false,"given":"Valentin","family":"Wucher","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/ UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-1558","authenticated-orcid":false,"given":"Virginie","family":"Desestret","sequence":"additional","affiliation":[{"name":"MeLis Institute, SynatAc Team, Inserm U1314\/UMR CNRS5284, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"French Reference Center on Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France"},{"name":"Hopital neurologique P.Wertheimer 59 Bd Pinel 69677 Bron 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associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung","volume":"2013","author":"Hasadsri L","year":"2013","unstructured":"Hasadsri L, Lee J, Wang BH, et al. Anti-Yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung. Case Rep Neurol Med 2013; 2013: 725936.","journal-title":"Case Rep Neurol Med"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh247"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1486"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.04.029"},{"issue":"3","key":"e_1_3_4_16_2","first-page":"275","article-title":"Paraneoplastic cerebellar degeneration and endometrial cancer: a rare occurrence","volume":"48","author":"Karpathiou G","year":"2016","unstructured":"Karpathiou G, Da Cruz V, Casteillo F, et al. Paraneoplastic cerebellar degeneration and endometrial cancer: a rare occurrence. 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