{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:45:41Z","timestamp":1788479141436,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Subcutaneous natalizumab (scN) was recently approved in Argentina for people with multiple sclerosis (pwMS). The impact of this change in this population is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the use, access and satisfaction of scN and correlate it with clinical and demographic variables. Desing: cross-sectional study was conducted, surveying pwMS who received scN and ivN from public and private MS Centres since its approval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Treatment adherence was assessed using the MS Treatment Adherence Questionnaire (MS-TAQ) and satisfaction using Treatment Satisfaction of Questionnaire for Medication (TSQM). Clinical and demographic variables were also recorded. Results: 84 pwMS were included, 58.3% female, mean EDSS: 2.4\u2009\u00b1\u20091.2, mean age: 34.8\u2009\u00b1\u200910.8\u2009years, mean disease duration: 7.8\u2009\u00b1\u20094.5\u2009years, mean time under\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      : 43.7\u2009\u00b1\u200928.7\u2009months, 45.2% na\u00efve of prior disease modifying treatments, 77.4% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200965) under scN (60.7%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200951 are switchers from ivN, 49% due to difficult access to an infusion centre); and 22.6% 8 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200919) under ivN. The main barrier for change from iv to sc was the refusal from health insurance. Of the total of pwMS, 42% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200936) had a delay or lack of at least one dose from their social insurance, all from public hospitals. We found an association between scN use and high scores on the convenience items of TSQM (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001,\n                      <jats:italic toggle=\"yes\">X<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200974), unlike ivN. Regardless of route of administration, most of pwMS showed high percentages of satisfaction in the effectiveness and global satisfaction items, without differences between ivN and scM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found a high rate of change to scN from ivN, associated with a higher score in the comfort and convenience items in people receiving scN, compared to ivN. Access barriers should be addressed in order to improve treatment comfort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864251385094","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T04:58:51Z","timestamp":1761195531000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Access, satisfaction, adherence and safety to subcutaneous natalizumab compared to intravenous natalizumab in multiple sclerosis in a real-life cohort: first report from Latin America"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-2419","authenticated-orcid":false,"given":"Berenice A.","family":"Silva","sequence":"first","affiliation":[{"name":"Secci\u00f3n Esclerosis M\u00faltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Peron 4190, Argentina CUEM, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Santajuliana","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Esclerosis M\u00faltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Casas","sequence":"additional","affiliation":[{"name":"CUEM, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"CUEM, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Pita","sequence":"additional","affiliation":[{"name":"CUEM, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Cohen","sequence":"additional","affiliation":[{"name":"CUEM, Hospital Ramos Mej\u00eda, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Hospital San Martin De La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena","family":"M\u00edguez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Esclerosis M\u00faltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"D\u2019Alessandro","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Esclerosis M\u00faltiple y enfermedades desmielinizantes, Hospital Italiano de Buenos Aires, Argentina"},{"name":"Hospital San Martin De La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001136"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1401483"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.07.007"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864241241382"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211019574"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.20588"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322326"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.707"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211003020"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00323.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103915"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.1687"},{"key":"e_1_3_4_16_2","unstructured":"Censos IdEy. 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