{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:30:13Z","timestamp":1793046613206,"version":"4.5.0"},"reference-count":143,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["National High Level Hospital Clinical Research Fun"],"award-info":[{"award-number":["National High Level Hospital Clinical Research Fun"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Multi-system comorbidities are common in patients with multiple sclerosis (PwMS) and significantly influence the disease\u2019s presentation and progression. A comorbidity is defined as an illness other than the specific disease of interest (in this case, MS). Generally, chronic or recurrent conditions are included, while transient conditions such as infection or concussion are excluded. Certain modifiable metabolic diseases in PwMS, such as hypertension, diabetes, dyslipidemia, and modifiable health factors such as smoking, alcohol, and obesity, are also considered part of MS comorbidity in this review, since these are risk factors not only for poor outcomes in MS but also for other vascular comorbidities in PwMS. Cohort studies and clinical trials have reported that comorbidity could have multiple adverse effects on MS. The purpose of this review is to summarize studies investigating modifiable risk factors of comorbidity of MS, as well as multiple body system comorbidities in MS, focusing on the influence these comorbidities have on MS outcomes. We aim to emphasize that the management of MS involves not only disease-modifying therapy, but also requires controlling and preventing modifiable risk factors for comorbidities and appropriate treatment of comorbidities, as these interventions may be equally crucial in improving the prognosis of MS.<\/jats:p>","DOI":"10.1177\/17562864251404455","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:15:52Z","timestamp":1768302952000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comorbidity and modifiable risk factors in multiple sclerosis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-8484","authenticated-orcid":false,"given":"Yao","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Dobson","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK"},{"name":"Department of Neurology, Royal London Hospital, Barts Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-1700","authenticated-orcid":false,"given":"Gavin","family":"Giovannoni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Rd, London E1 1FR, UKBlizard Institute, Barts &amp; The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark St, London E1 2AT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13819"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564491"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2015.08.005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1197195"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000333252.78173.5f"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004716"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-127"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004885"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002543"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004686"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002564"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001718"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564485"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002474"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00363-2"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10107-y"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10194-x"},{"issue":"1","key":"e_1_3_4_20_2","article-title":"Comorbidity in multiple sclerosis past, present and future","volume":"42","author":"Marrie RA.","year":"2019","unstructured":"Marrie RA. Comorbidity in multiple sclerosis past, present and future. Clin Investig Med 2019; 42(1): E5\u2013E12.","journal-title":"Clin Investig Med"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.02.012"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25768-0"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.4065\/84.8.741"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12598"},{"issue":"11","key":"e_1_3_4_26_2","article-title":"Alemtuzumab versus interferon beta 1a for relapsing-remitting multiple sclerosis","volume":"11","author":"Zhang J","year":"2017","unstructured":"Zhang J, Shi S, Zhang Y, et al. Alemtuzumab versus interferon beta 1a for relapsing-remitting multiple sclerosis. Cochrane Database Syst Rev 2017; 11(11): CD010968.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"e_1_3_4_27_2","first-page":"180","article-title":"Follow-up of hypertension in patients with multiple sclerosis","volume":"15","author":"Baghbanian SM.","year":"2016","unstructured":"Baghbanian SM. Follow-up of hypertension in patients with multiple sclerosis. Iran J Neurol 2016; 15(3): 180\u2013181.","journal-title":"Iran J Neurol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002481"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564487"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564488"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.05.002"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02971.x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.418"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-05871-w"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.06.021"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564490"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102650"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209885"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2013.03.001"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016149"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.07.020"},{"issue":"2","key":"e_1_3_4_42_2","first-page":"312","article-title":"Effect of smoking on multiple sclerosis: a meta-analysis","volume":"39","author":"Poorolajal J","year":"2017","unstructured":"Poorolajal J, Bahrami M, Karami M, et al. Effect of smoking on multiple sclerosis: a meta-analysis. J Public Health (Oxf) 2017; 39(2): 312\u2013320.","journal-title":"J Public Health (Oxf)"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506073501"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518791753"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b2a706"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.122"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2326-7"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5858"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1159\/000323948"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2021.0075.r1.14092021"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101842"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10304"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182553c5b"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep\/31.7.944"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4044"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10935-6"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.04.003"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.08.033"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105841"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512437814"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105879"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101987"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2024.101551"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516650512"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14557"},{"key":"e_1_3_4_66_2","article-title":"Chronic diseases in male veterans with multiple sclerosis","volume":"9","author":"Lavela SL","year":"2012","unstructured":"Lavela SL, Prohaska TR, Furner S, et al. Chronic diseases in male veterans with multiple sclerosis. Prev Chronic Dis 2012; 9: E55.","journal-title":"Prev Chronic Dis"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-329685"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12331-2"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1366-7"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8295-9"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320245"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103501"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1159\/000128103"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104444"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2013.06.006"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101423"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513475833"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-023-02848-0"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103279"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.067"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2020-300207"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7041-9"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104954"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045295"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-07034-x"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2024.11.002"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105103"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01128-8"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6790-1"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508088936"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51495"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2017-0047"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105546"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.12.012"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74298-0"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510369146"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01355.x"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13175015"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.05.008"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2012.06.001"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585241247775"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511426737"},{"issue":"4","key":"e_1_3_4_103_2","article-title":"Incidence of malignancy in multiple sclerosis: a cohort study in the Danish Multiple Sclerosis Registry","volume":"7","author":"Norgaard M","year":"2021","unstructured":"Norgaard M, Veres K, Sellebjerg FT, et al. Incidence of malignancy in multiple sclerosis: a cohort study in the Danish Multiple Sclerosis Registry. Mult Scler J Exp Transl Clin 2021; 7(4): 20552173211053939.","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000227"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12267"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25247"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508092263"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14040"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01436.x"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0183-3"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.2165\/11532120-000000000-00000"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.061"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011913"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209135"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S148387"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnu.2007.02.008"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004508"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010024"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148573"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100028523"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2920"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.1.20"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1159\/000442203"},{"key":"e_1_3_4_124_2","doi-asserted-by":"crossref","unstructured":"Wu J Alfredsson L Olsson T et al. Obesity affects disease activity and progression cognitive functioning and quality of life in people with multiple sclerosis 2025; 12(1): e200334.","DOI":"10.1212\/NXI.0000000000200334"},{"issue":"2","key":"e_1_3_4_125_2","first-page":"83","article-title":"Restless legs syndrome in patients with multiple sclerosis: evaluation of risk factors and clinical impact","volume":"37","author":"Hernandez LL","year":"2022","unstructured":"Hernandez LL, Le\u00f3n MP, Fuentes NAC, et al. Restless legs syndrome in patients with multiple sclerosis: evaluation of risk factors and clinical impact. Neurologia (Engl Ed) 2022; 37(2): 83\u201390.","journal-title":"Neurologia (Engl Ed)"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d6b125"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.10.020"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2010.04.002"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt139"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1788"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103308"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318248deea"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01532.x"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004686"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200105000-00004"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01526.x"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-54"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507078393"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000269"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2018.06.001"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012610"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829a3388"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315907"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864251404455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864251404455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864251404455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T17:42:02Z","timestamp":1769362922000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864251404455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":143,"alternative-id":["10.1177\/17562864251404455"],"URL":"https:\/\/doi.org\/10.1177\/17562864251404455","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"17562864251404455"}}