{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T18:48:07Z","timestamp":1770403687598,"version":"3.49.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cerebrovascular events are a potentially serious complication of giant cell arteritis (GCA) with intracranial involvement. However, diagnosing GCA in this context remains challenging, as classical clinical features may be absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To identify characteristic cerebellar infarct patterns associated with intracranial GCA and to differentiate them from other common causes of posterior circulation stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Multicenter retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 125 patients with cerebellar infarctions of various etiologies were included. Among these, 19 patients had confirmed intracranial GCA. Infarct patterns were compared to those seen in strokes of cardioembolic origin (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200942), arterio-arterial embolism from proximal vertebral artery atherosclerosis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200913), local atherosclerotic stenosis of the V4 segment (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200921), and vertebral artery dissection (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200930). Infarct topography was assessed using acute-phase diffusion-weighted magnetic resonance imaging. Sensitivity and specificity were calculated for individual imaging features.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Distinct imaging signatures were observed in patients with GCA. A \u201ccorona-like\u201d infarct pattern, defined by sparing of the medial branch of the proximal posterior inferior cerebellar artery (PICA), demonstrated a sensitivity of 79% and a specificity of 64%. A patchy infarct pattern, characterized by scattered non-confluent lesions, was present in 53% of GCA cases and showed high specificity (93%). When both features were present, specificity increased to 98% and sensitivity was reduced to 47%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings reveal a distinct cerebellar infarct pattern associated with intracranial GCA, characterized by a corona-like configuration and patchy lesions predominantly involving the lateral PICA territory. Recognition of this imaging phenotype may enhance diagnostic accuracy in challenging cases and facilitate the timely initiation of immunosuppressive therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864251405203","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:11:48Z","timestamp":1770192708000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A corona-like distribution and patchy pattern of cerebellar infarcts identify patients with giant cell arteritis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-0357","authenticated-orcid":false,"given":"Carolin","family":"Beuker","sequence":"first","affiliation":[{"name":"Department of Neurology, University of M\u00fcnster, Albert-Schweitzer-Campus 1, Geb\u00e4ude A1, M\u00fcnster 48149, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Kolja","family":"Strecker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Schleswig-Holstein and University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veith","family":"Jungmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Werring","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Schleswig-Holstein and University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Brix","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian Christian","family":"Wankner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Schmidt-Pogoda","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Stracke","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, University Hospital of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Eckert","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Asklepios Klinik Hamburg Altona, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-9273","authenticated-orcid":false,"given":"Thomas Raphael","family":"Meinel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Schaumberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Community Hospital Sana Kliniken L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schulamith","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helios Klinikum Uelzen, Uelzen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milani","family":"Deb-Chatterji","sequence":"additional","affiliation":[{"name":"University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Magnus","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, 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