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This incisionless, image-guided technique targets the ventralis intermedius nucleus of the thalamus with precision, sparing surrounding eloquent tissue.<\/jats:p>\n                    <jats:p>Objective: This study aims to assess the efficacy of MRgFUS thalamotomy in improving tremor among ET patients, as objectively measured by a tri-axis accelerometer, and to compare these objective measures with the conventional Clinical Rating Scale for Tremor (CRST).<\/jats:p>\n                    <jats:p>Design: Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ten ET patients (aged 68.1\u2009\u00b1\u200911.8\u2009years) received the MRgFUS treatment. Improvements in tremor severity were assessed using primary (CRST), with additional measurements of kinematic feature obtained from a tri-axis accelerometer. Correlations between accelerometer-derived kinematic features and CRST scores were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Significant improvement in tremor severity was observed in the cohort, as measured by both the accelerometer and CRST (paired Student\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) before and 1\u2009day after the treatment. A moderate-to-strong correlation was found between accelerometer measurements and CRST scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The tri-axis accelerometer provides an effective means of monitoring tremor reduction following MRgFUS and correlated well to the clinical scales like CRST. This study supports the feasibility of accelerometer-based monitoring in clinical practice for MRgFUS assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864251406534","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:37:23Z","timestamp":1769683043000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Objective tremor monitoring using tri-axis accelerometer in MRgFUS thalamotomy for essential tremor: a feasibility study"],"prefix":"10.1177","volume":"19","author":[{"given":"Kai-Chun","family":"Liu","sequence":"first","affiliation":[{"name":"College of Information and Computer Sciences, University of Massachusetts Amherst, Amherst, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Macerollo","sequence":"additional","affiliation":[{"name":"The Walton Centre NHS Foundation Trust for Neurology and Neurosurgery, Liverpool, UK"},{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon-Ming","family":"Heng","sequence":"additional","affiliation":[{"name":"Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Neurology, China Medical University Hsinchu Hospital, Zhubei City, Taiwan"},{"name":"Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Chiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, China Medical University Hsinchu Hospital, Zhubei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Kuei","family":"Lu","sequence":"additional","affiliation":[{"name":"Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan"},{"name":"Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Division of Parkinson\u2019s Disease and Movement Disorders, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan"},{"name":"Department of Radiology, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chon-Haw","family":"Tsai","sequence":"additional","affiliation":[{"name":"Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan"},{"name":"Division of Parkinson\u2019s Disease and Movement Disorders, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7146-1482","authenticated-orcid":false,"given":"Jui-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, China Medical University, No. 2, Yuh-Der Road, Taichung 404327, Taiwan"},{"name":"Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan"},{"name":"Stroke Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.11.04028"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22838"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27121"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0294-x"},{"issue":"6","key":"e_1_3_4_6_2","first-page":"596","article-title":"Essential tremor","volume":"379","author":"Haubenberger D","year":"2018","unstructured":"Haubenberger D, Hallett M. 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