{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:08:03Z","timestamp":1773302883553,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Emalex Biosciences, Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>What is this summary about?<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>The purpose of this summary is to explain the results from two studies that looked at the safety and effects of an investigational drug called ecopipam. \u201cInvestigational\u201d means that the drug has not been approved by the United States Food and Drug Administration (FDA) yet. The studies tested if ecopipam could safely improve symptoms and quality of life in children and adolescents with Tourette syndrome.<\/jats:p>\n                  <jats:p>Please note that ecopipam is not currently approved to treat Tourette syndrome.<\/jats:p>","DOI":"10.1177\/17562864261424987","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:28:40Z","timestamp":1772159320000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plain Language Summary of a Phase 2b Randomized Controlled Trial of Ecopipam and Its 12-Month Open-Label Extension in Children and Adolescents With Tourette Syndrome"],"prefix":"10.1177","volume":"19","author":[{"given":"Donald L.","family":"Gilbert","sequence":"first","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J. B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Emalex Biosciences, Inc., Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Emalex Biosciences, Inc., Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah D.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Emalex Biosciences, Inc., Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George B.","family":"Karkanias","sequence":"additional","affiliation":[{"name":"Emalex Biosciences, Inc., Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick E.","family":"Munschauer","sequence":"additional","affiliation":[{"name":"Emalex Biosciences, Inc., Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen P.","family":"Wanaski","sequence":"additional","affiliation":[{"name":"Paragon Biosciences, LLC, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Cunniff","sequence":"additional","affiliation":[{"name":"Paragon Biosciences, LLC, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,26]]},"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864261424987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864261424987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864261424987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:30:33Z","timestamp":1773235833000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864261424987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":0,"alternative-id":["10.1177\/17562864261424987"],"URL":"https:\/\/doi.org\/10.1177\/17562864261424987","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"article-number":"17562864261424987"}}