{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:12:34Z","timestamp":1788667954105,"version":"build-2803163510"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006314","name":"Biogen Idec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Natalizumab (NTZ) is a highly effective disease-modifying therapy for relapsing-remitting multiple sclerosis (RRMS), originally administered intravenously (IV). A subcutaneous formulation (SC_NTZ) became available in Switzerland in 2021, offering potential advantages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate satisfaction and convenience of use of SC_NTZ in MS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Swiss, prospective, multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive RRMS patients treated with either \u2a7d6 (starters) or &gt;\u20096 (long-term users) SC_NTZ injections completed the Treatment Satisfaction Questionnaire with Medication-II (TSQM-II, higher scores indicating greater satisfaction) and the Patient Satisfaction Questionnaire (PSQ) at baseline (Visit 1, V1). Starters were reassessed at the 9th SC_NTZ dose (Visit 2, V2). Non-parametric tests were applied to compare long-term users with starters at V1, and changes from V1 to V2 in starters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred six patients (73.6% female, median age 39.6\u2009years, prior IV_NTZ 81.1%) were enrolled, including 79 long-term users and 27 starters. At V1, in the overall group the median (IQR) TSQM-II effectiveness, side effects, convenience and global satisfaction scores were 83 (67\u2013100), 100 (92\u2013100), 83 (72\u201389) and 83 (75\u2013100), respectively. On the PSQ, the most commonly cited benefit was short administration time (80.2%). SC_NTZ treatment \u201cnever\u201d affected work attendance in 54\/87 (62.1%) employed patients. Seventy-nine percent participants reported spending \u2a7d1\u2009h for SC_NTZ administration. Nonetheless, 76\/86 (88.4%) of switchers from IV_NTZ found opportunities for discussions with healthcare professionals to be \u201csimilar\u201d\/\u201dimproved,\u201d and 78 (90.7%) preferred SC_NTZ. Findings were consistent across subgroups and time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This real-world, multicenter Swiss study supports SC_NTZ as a well-tolerated, highly accepted, and patient-preferred alternative to IV_NTZ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864261431414","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:42:26Z","timestamp":1788435746000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient SAtisfaction with the TYSabri SC Formulation \u2013 A Swiss multi-centriC, prospective non-intervenTIONal study: the SATYSFACTION study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-3431","authenticated-orcid":false,"given":"Chiara","family":"Zecca","sequence":"first","affiliation":[{"name":"Neurocenter of Southern Switzerland, EOC, Via Tesserete, 46, Lugano, CH, 6900, Switzerland Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilio","family":"Disanto","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland"},{"name":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-5534","authenticated-orcid":false,"given":"Gianna Carla","family":"Riccitelli","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland"},{"name":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-4649","authenticated-orcid":false,"given":"Rosaria","family":"Sacco","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland"},{"name":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Noseda","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Findling","sequence":"additional","affiliation":[{"name":"Kantonsspital Aarau, Klinik f\u00fcr Neurologie, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirstian","family":"Kamm","sequence":"additional","affiliation":[{"name":"Neurocenter, Lucerne Cantonal Hospital, Lucerne, Switzerland"},{"name":"Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Pot","sequence":"additional","affiliation":[{"name":"Service of Neurology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Neurocenter of Southern Switzerland, EOC, Lugano, Switzerland"},{"name":"Faculty of biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01473-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.05.049"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044396"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"e_1_3_4_6_2","unstructured":"Tysabri\u2122 product information https:\/\/www.swissmedicinfo.ch; https:\/\/www.ema.europa.eu (2021)."},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.707"},{"issue":"10","key":"e_1_3_4_8_2","first-page":"1531","article-title":"A randomized study of natalizumab dosing regimens for relapsing-remitting multiple sclerosis","volume":"27","author":"Trojano M","year":"2021","unstructured":"Trojano M, Ramio-Torrenta L, Grimaldi LME, et al. A randomized study of natalizumab dosing regimens for relapsing-remitting multiple sclerosis. Mult Scler 2021; 27(10): 1531\u20131540.","journal-title":"Mult Scler"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30282-X"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.00066.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1063904"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864241241382"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864251385094"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1049732303259618"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S115090"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-025-00725-x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04838-z"}],"container-title":["Therapeutic Advances in Neurological Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864261431414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562864261431414","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562864261431414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:50:09Z","timestamp":1788666609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562864261431414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":17,"alternative-id":["10.1177\/17562864261431414"],"URL":"https:\/\/doi.org\/10.1177\/17562864261431414","relation":{},"ISSN":["1756-2864","1756-2864"],"issn-type":[{"value":"1756-2864","type":"print"},{"value":"1756-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"17562864261431414"}}