{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:49:05Z","timestamp":1774961345000,"version":"3.50.1"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"china scholarship council","doi-asserted-by":"publisher","award":["202106245020"],"award-info":[{"award-number":["202106245020"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271331"],"award-info":[{"award-number":["82271331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Neurol Disord"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Current guidelines consider mechanical thrombectomy (MT) reasonable for M2 segment middle cerebral artery (MCA) occlusions within 6\u2009h of symptom onset, yet the impact of delayed intervention in this population remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study compared effectiveness and safety outcomes of MT performed in late (&gt;6\u2009h) versus early (\u2a7d6\u2009h) treatment windows in patients with acute primary embolic M2 occlusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients with primary embolic M2 occlusions treated with MT within 24\u2009h of onset from the ARTISTA (A Registry for Thrombectomy In Stroke Therapy from Andalusia) registry (2017\u20132024) in Seville-Huelva, Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Outcomes compared between late and early treatment groups included good outcome (90-day modified Rankin Scale (mRS) 0\u20132 or return to prestroke mRS), futile recanalization (FR; 90-day mRS &gt;2 despite successful recanalization), successful recanalization (modified Thrombolysis in Cerebral Infarction \u2a7e2b), and symptomatic intracranial hemorrhage (sICH). Multivariable logistic regression and inverse probability of treatment weighting (IPTW) analyses were performed to evaluate associations between treatment window and MT outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 524 patients (median age 76, 48.3% women), 207 (39.5%) underwent MT in the late window. Late treatment showed numerically lower rates of good outcome (58.9% vs 64.4%) and higher rates of FR (37.8% vs 32.5%) and sICH (3.4% vs 3.2%), though none were statistically significant (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2a7e0.211). Successful recanalization rates were nearly identical between the late and early windows (95.7% vs 95.6%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.970). IPTW-adjusted analyses also found no significant differences in good outcome (adjusted odds ratio (aOR), 0.82; 95% confidence interval (CI), 0.39\u20131.73;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.600) or FR (aOR, 1.19; 95% CI, 0.56\u20132.50;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.653) at 90\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this multicenter real-world cohort, MT performed beyond 6\u2009h showed effectiveness and safety outcomes comparable to early-window intervention in patients with primary embolic MCA M2 occlusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562864261434562","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:19:51Z","timestamp":1774779591000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of mechanical thrombectomy in acute stroke due to primary embolic middle cerebral artery M2 occlusions: a comparison of late versus early windows"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-5359","authenticated-orcid":false,"given":"Huan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Center of Cerebrovascular Diseases, West China Hospital, Sichuan University, Chengdu, 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Roc\u00edo University Hospital, Neurovascular Research Laboratory, Institute of Biomedicine of Seville, Seville, Spain"},{"name":"Stroke Unit, Neurovascular Research Program, Seville Biomedical Research Institute, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asier","family":"de Alb\u00f3niga-Chindurza","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Unit, Radiology Department, Virgen del Roc\u00edo University Hospital, Neurovascular Research Laboratory, Institute of Biomedicine of Seville, Seville, Spain"},{"name":"Stroke Unit, Neurovascular Research Program, Seville Biomedical Research Institute, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Antonio","family":"Andrade Ruiz","sequence":"additional","affiliation":[{"name":"Methodological and Statistical Management Unit, Foundation for Health Research Management, FISEVI, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Stroke Unit, Neurovascular Research Program, Seville Biomedical Research Institute, Seville 41013, Spain"},{"name":"Neurology Department, Virgen Macarena University Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Gonz\u00e1lez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Unit, Radiology Department, Virgen del Roc\u00edo University Hospital, Neurovascular Research Laboratory, Institute of Biomedicine of Seville, Av Manuel Siurot sn, Seville 41013, Spain"},{"name":"Stroke Unit, Neurovascular Research Program, Seville Biomedical Research Institute, Seville, 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Safety and efficacy of MCA-M2 thrombectomy in delayed time window: a propensity score analysis from the STAR registry. 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