{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:29:16Z","timestamp":1775093356248,"version":"3.50.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> The aim of this study was to verify the efficacy and safety of intravesical treatment combining sodium hyaluronate (HA) and chondroitin sulfate (CS) in patients with interstitial cystitis\/bladder pain syndrome (IC\/BPS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Between February 2010 and May 2011, 20 consecutive women with IC\/BPS were treated with intravesical instillations containing sodium HA (1.6%; 800 mg\/50 ml) and sodium CS (2%; 1 g\/50 ml) weekly for the first month, biweekly for the second month, and then monthly for at least 3 months. Before and after treatment, all patients filled in the Interstitial Cystitis Symptom Index and Problem Index (ICSI\/ICPI), the Patient Health Questionnaire 9 and the Pelvic Pain and Urgency\/Frequency Patient Symptom Scale (PUF). Treatment efficacy was assessed by comparing the pre- and post-treatment mean scores of the three questionnaires using Student\u2019s t test ( p value &lt;0.05 was considered significant). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Statistically significant mean decreases in ICSI (from 13.0 to 9.3; p = 0.0003), ICPI (from 11.35 to 8.85; p = 0.0078) and PUF (from 20.0 to 15.75; p = 0.0007) questionnaire scores were seen. No cases of side effects or complications were observed. The mean follow up was 5 months. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Despite the limitations of this study, the outcomes confirmed the role of combination therapy with HA and CS as a safe and effective option for the treatment of IC\/BPS. Further randomized controlled studies with a higher number of patients and a longer follow-up period are needed to confirm these results. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756287213490052","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T03:04:19Z","timestamp":1371524659000},"page":"175-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Combined intravesical sodium hyaluronate\/chondroitin sulfate therapy for interstitial cystitis\/bladder pain syndrome: a prospective study"],"prefix":"10.1177","volume":"5","author":[{"given":"Claudio","family":"Giberti","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, San Paolo Hospital, Savona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Gallo","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, San 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6,17]]},"reference":[{"key":"bibr1-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-007-0443-4"},{"key":"bibr2-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2011.06.001"},{"key":"bibr3-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.06.1089"},{"key":"bibr4-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-008-0572-4"},{"key":"bibr5-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1177\/1756287211418723"},{"key":"bibr6-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.12.039"},{"key":"bibr7-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.08.020"},{"key":"bibr8-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.07.069"},{"key":"bibr9-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05776.x"},{"key":"bibr10-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.064"},{"key":"bibr11-1756287213490052","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.03.020"},{"key":"bibr12-1756287213490052","doi-asserted-by":"publisher","DOI":"10.3928\/0048-5713-20020901-06"},{"key":"bibr13-1756287213490052","first-page":"405","volume":"56","author":"Mahmoud 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