{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:29:46Z","timestamp":1763641786365,"version":"3.38.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Introduction:<\/jats:title><jats:p> Peyronie\u2019s disease (PD) is a chronic wound-healing disorder characterized by formation of fibrous inelastic scarring of the tunica albuginea resulting in a variety of penile deformities. In most cases, PD is accompanied by a physical and psychological impact. Xiaflex\u00ae is an injectable collagenase clostridium histolyticum (CCh) preparation consisting of a predetermined mixture of two distinct collagenases. Recently the US Food and Drug Administration (FDA) approved Xiaflex\u00ae for the nonsurgical treatment of men with PD with curvature of 30\u00b0 or more and tangible scar tissue plaque in their penis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> This article presents a comprehensive review of the updated information on the use of Xiaflex\u00ae for the nonsurgical treatment of PD. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Mean improvements in penile curvature ranging from 29% to 34% and in bother domain scores have been reported. The majority of the reported adverse effects are mild or moderate and 79% resolve without intervention. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The combined results of these trials have led to the FDA approval of CCh for the treatment of PD. However, the long-term effects and results need further investigation, with large follow-up series. Considering these results, future perspectives will probably result in the use of a combined or sequential therapy including CCh. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756287214537331","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T01:56:13Z","timestamp":1403142973000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Experience in the use of collagenase clostridium histolyticum in the management of Peyronie\u2019s disease: current data and future prospects"],"prefix":"10.1177","volume":"6","author":[{"given":"Mar\u00eda Alejandra","family":"Egui Rojo","sequence":"first","affiliation":[{"name":"Urology Department, Hospital Universitario de Fuenlabrada, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Moncada Iribarren","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital de la Zarzuela, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Carballido Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Ignacio","family":"Martinez-Salamanca","sequence":"additional","affiliation":[{"name":"Department of Urology, Hospital Puerta de Hierro-Majadahonda, Universidad Aut\u00f3noma de Madrid, C\/ Manuel de Falla no. 1, Majadahonda 28222, Madrid, 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