{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:00:59Z","timestamp":1789066859924,"version":"build-2803163510"},"reference-count":98,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome\/interstitial cystitis (BPS\/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Identification of a novel mediator of bladder inflammation and pain could lead to emerging new therapeutic strategy and the first causative therapy. <\/jats:p>","DOI":"10.1177\/1756287218818030","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T19:47:26Z","timestamp":1547063246000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis"],"prefix":"10.1177","volume":"11","author":[{"given":"Karol Borys","family":"Tudrej","sequence":"first","affiliation":[{"name":"Medical University of Warsaw, Banacha 1, Warszawa, Mazowieckie, 02-097, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Piecha","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw, Warszawa, Mazowieckie, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Koz\u0142owska-Wojciechowska","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw, Warszawa, Mazowieckie, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"bibr1-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086"},{"key":"bibr2-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"bibr3-1756287218818030","volume-title":"EAU guidelines on chronic pelvic pain","author":"Engeler D","year":"2017"},{"key":"bibr4-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.11.084"},{"key":"bibr5-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.088"},{"key":"bibr6-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0285-5"},{"key":"bibr7-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-007-9181-2"},{"key":"bibr8-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.103"},{"key":"bibr9-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"bibr10-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4364-2"},{"key":"bibr11-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-006-0051-8"},{"key":"bibr12-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199010000-00011"},{"key":"bibr13-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2014.01.11"},{"key":"bibr14-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1998.tb00238.x"},{"key":"bibr15-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.10.s1.4.x"},{"key":"bibr16-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1108"},{"key":"bibr17-1756287218818030","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1632522.261"},{"key":"bibr18-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1111\/his.13235"},{"key":"bibr19-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03640.x"},{"key":"bibr20-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1177\/1756287211398255"},{"key":"bibr21-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1109"},{"key":"bibr22-1756287218818030","first-page":"563","volume":"4","author":"Hurst RE","year":"2015","journal-title":"Transl Androl Urol"},{"key":"bibr23-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32495-3"},{"key":"bibr24-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.010"},{"key":"bibr25-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12565"},{"key":"bibr26-1756287218818030","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1632712.356"},{"key":"bibr27-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.082401.104914"},{"key":"bibr28-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.100"},{"key":"bibr29-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9392-x"},{"key":"bibr30-1756287218818030","first-page":"579","volume":"4","author":"Theoharides TC","year":"2015","journal-title":"Transl Androl Urol"},{"key":"bibr31-1756287218818030","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00114"},{"key":"bibr32-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0243-0"},{"key":"bibr33-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22542"},{"key":"bibr34-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.11.099"},{"key":"bibr35-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076779"},{"key":"bibr36-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1159\/000355175"},{"key":"bibr37-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000224"},{"key":"bibr38-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1993.tb00720.x"},{"key":"bibr39-1756287218818030","volume-title":"You don\u2019t have to live with cystitis!","author":"Gillespie L","year":"1996"},{"key":"bibr40-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63178-1"},{"key":"bibr41-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)01110-9"},{"key":"bibr42-1756287218818030","first-page":"15","volume":"7","author":"Osborne J.","year":"2010","journal-title":"IC Optimist"},{"key":"bibr43-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2009.1702"},{"key":"bibr44-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182044"},{"key":"bibr45-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00322-6"},{"key":"bibr46-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23284"},{"key":"bibr47-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.09.022"},{"key":"bibr48-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1177\/039463200501800119"},{"key":"bibr49-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)00046-1"},{"key":"bibr50-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.05.003"},{"key":"bibr51-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.05.003"},{"key":"bibr52-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.197822"},{"key":"bibr53-1756287218818030","first-page":"15","volume":"8","author":"Ozaki E","year":"2015","journal-title":"J Inflamm Res"},{"key":"bibr54-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2707"},{"key":"bibr55-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01070-6"},{"key":"bibr56-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2015.03.021"},{"key":"bibr57-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36120-7"},{"key":"bibr58-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.020"},{"key":"bibr59-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0b013e3182044b5c"},{"key":"bibr60-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.05257.x"},{"key":"bibr61-1756287218818030","first-page":"15","volume":"7","author":"Osborne J","year":"2010","journal-title":"IC Optimist"},{"key":"bibr62-1756287218818030","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"bibr63-1756287218818030","first-page":"47","volume":"270","author":"O\u2019Neill LA.","year":"2002","journal-title":"Curr Top Microbiol Immunol"},{"key":"bibr64-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"bibr65-1756287218818030","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100229"},{"key":"bibr66-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.6"},{"key":"bibr67-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1126-6"},{"key":"bibr68-1756287218818030","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.7.3749"},{"key":"bibr69-1756287218818030","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300354"},{"key":"bibr70-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1177\/09680519060120040201"},{"key":"bibr71-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nri3452"},{"key":"bibr72-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.009"},{"key":"bibr73-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663"},{"key":"bibr74-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nature04515"},{"key":"bibr75-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/srep39884"},{"key":"bibr76-1756287218818030","doi-asserted-by":"publisher","DOI":"10.2174\/1389450117666160817103435"},{"key":"bibr77-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.03.020"},{"key":"bibr78-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"bibr79-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"bibr80-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nature10510"},{"key":"bibr81-1756287218818030","first-page":"1","volume":"2016","author":"Li H","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"bibr82-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006171"},{"key":"bibr83-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90490-5"},{"key":"bibr84-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40201-1"},{"key":"bibr85-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00607.2015"},{"key":"bibr86-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00607.2015"},{"key":"bibr87-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A7101.2006"},{"key":"bibr88-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2237"},{"key":"bibr89-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"bibr90-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00297.2013"},{"key":"bibr91-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23414"},{"key":"bibr92-1756287218818030","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000396"},{"key":"bibr93-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.09.007"},{"key":"bibr94-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0087OC"},{"key":"bibr95-1756287218818030","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8614.1"},{"key":"bibr96-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"bibr97-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200903124"},{"key":"bibr98-1756287218818030","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-017-6725-2"}],"container-title":["Therapeutic Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756287218818030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1756287218818030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756287218818030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T06:20:32Z","timestamp":1741069232000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1756287218818030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":98,"alternative-id":["10.1177\/1756287218818030"],"URL":"https:\/\/doi.org\/10.1177\/1756287218818030","relation":{},"ISSN":["1756-2872","1756-2880"],"issn-type":[{"value":"1756-2872","type":"print"},{"value":"1756-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"1756287218818030"}}