{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:56:53Z","timestamp":1790146613981,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate whether autologous stem-cell-based therapy may mitigate the symptoms of interstitial cystitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Stromal vascular fraction (SVF) rich in stem cells and derived from autologous adipose tissue was deployed into 109 men and women with interstitial cystitis\/painful bladder syndrome as a surgical procedure. This stem-cell-rich biologic product was injected both systemically and regionally into pelvic floor targets. Patients were queried about quality of life and symptom and bother subjective outcomes tests every 3\u2009months for 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 78 patients reported a positive response at 1\u2009year. Symptom and bother metrics were statistically improved at 1\u2009year. There were minimal adverse events associated with the harvesting, procurement, and clinical deployment of SVF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Interstitial cystitis is a complex clinical problem that is known for its resistance to conventional therapies. SVF as an autologous personalized regenerative strategy shows good safety and efficacy and may potentially have a role in the mitigation of interstitial cystitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1756287219868590","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T03:27:58Z","timestamp":1566012478000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Personal cell therapy for interstitial cystitis with autologous stromal vascular fraction stem cells"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-3397","authenticated-orcid":false,"given":"Elliot B.","family":"Lander","sequence":"first","affiliation":[{"name":"Cell Surgical Network, 72780 Country Club Drive #301, Rancho Mirage, CA 92270, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Berman","sequence":"additional","affiliation":[{"name":"Cell Surgical Network, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie R.","family":"See","sequence":"additional","affiliation":[{"name":"Cell Surgical Network, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.133"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67637-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S58853"},{"key":"e_1_3_3_6_2","first-page":"592","article-title":"Focused issue on interstitial cystitis\/blader pain syndrome (IC\/BPS)","volume":"4","author":"Sant GR","year":"2015","unstructured":"Sant GR, Saban R. 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