{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:46:05Z","timestamp":1793054765208,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> The treatment landscape for metastatic urothelial cancer (mUC) beyond first-line platinum-based chemotherapy has changed significantly over the last 5\u2009years with the recent approvals of the immune checkpoint inhibitors (ICIs), fibroblast growth factor receptor (FGFR) inhibitors and most recently Enfortumab Vedotin (EV). EV is a novel antibody\u2013drug conjugate (ADC), that delivers monomethyl auristatin E (MMAE), a microtubule-disrupting agent, inside cells harboring the cell surface nectin-4 receptor. In mUC, EV has shown encouraging response rates and received accelerated approval from the Food and Drug Administration (FDA) in December 2019 in the post-platinum and ICI setting. EV is generally well tolerated, with the main toxicities being neuropathy, skin rash, alopecia and fatigue. Notably EV can also be administered to patients with renal dysfunction, which is commonly a concern in this patient population. EV is now being tested in combination strategies and in earlier disease settings in urothelial cancers. In this review, we will discuss its mechanism of action, clinical trials leading to FDA approval as well as ongoing trials and future directions. <\/jats:p>","DOI":"10.1177\/1756287220980192","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T06:42:12Z","timestamp":1609137732000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Enfortumab Vedotin in urothelial cancer"],"prefix":"10.1177","volume":"12","author":[{"given":"Marie","family":"Alt","sequence":"first","affiliation":[{"name":"Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Stecca","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swanee","family":"Tobin","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-2292","authenticated-orcid":false,"given":"Di Maria","family":"Jiang","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-1285","authenticated-orcid":false,"given":"Srikala S.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Medicine, Medical Oncologist, Princess Margaret Cancer Center, Chair, GU Medical Oncologists of Canada, 7-625 OPG, 610 University Avenue, Toronto, ON M5G 2M9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,27]]},"reference":[{"key":"bibr1-1756287220980192","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"bibr2-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3068"},{"key":"bibr3-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613683"},{"key":"bibr4-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.4505"},{"key":"bibr5-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5534"},{"key":"bibr6-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817323"},{"key":"bibr7-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01140"},{"key":"bibr8-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000310"},{"key":"bibr9-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318172d704"},{"key":"bibr10-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.03.023"},{"key":"bibr11-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2250"},{"key":"bibr12-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.268"},{"key":"bibr13-1756287220980192","first-page":"8789","volume":"15","author":"Zhang Y","year":"2018","journal-title":"Oncol Lett"},{"key":"bibr14-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1313"},{"key":"bibr15-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1763-4"},{"key":"bibr16-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02044"},{"key":"bibr17-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz249.020"},{"key":"bibr18-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0198"},{"key":"bibr19-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78154-9_2"},{"key":"bibr20-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.6_suppl.441"},{"key":"bibr21-1756287220980192","doi-asserted-by":"crossref","first-page":"v888","DOI":"10.1093\/annonc\/mdz394.047","volume":"30","author":"Grande E","year":"2019","journal-title":"Ann Oncol"},{"key":"bibr22-1756287220980192","first-page":"38","author":"Powles T","year":"2020","journal-title":"J Clin Oncol"},{"key":"bibr23-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.10.026"},{"key":"bibr24-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0628-7"},{"key":"bibr25-1756287220980192","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814017"},{"key":"bibr26-1756287220980192","volume-title":"Presented at the European Society of Medical Oncology Annual Virtual Meeting","author":"Loriot Y","year":"2020"}],"container-title":["Therapeutic Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756287220980192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1756287220980192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756287220980192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:39:04Z","timestamp":1740829144000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1756287220980192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":26,"alternative-id":["10.1177\/1756287220980192"],"URL":"https:\/\/doi.org\/10.1177\/1756287220980192","relation":{},"ISSN":["1756-2872","1756-2880"],"issn-type":[{"value":"1756-2872","type":"print"},{"value":"1756-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1756287220980192"}}