{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:29:39Z","timestamp":1784662179993,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> Radical cystectomy (RC) is a complex urologic procedure performed for the treatment of bladder cancer and causes significant morbidity. Wound dehiscence (WD) is a major complication associated with RC and is associated with multiple risk factors. The objectives of this study are to identify clinical risk factors for incidence of WD and develop a risk-prediction model to aid in patient risk-stratification and improvement of perioperative care. <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p> The American College of Surgeons \u2013 National Surgical Quality Improvement Program (ACS-NSQIP) database was used to derive the study cohort. A univariate analysis provided nine variables eligible for multivariate model entry. A stepwise logistic regression analysis was conducted and refined considering clinical relevance of the variables, and then bootstrapped with 1000 samples, resulting in a five-factor model. Model performance and calibration were assessed by a receiver operated curve (ROC) analysis and the Hosmer\u2013Lemeshow test for goodness of fit, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A cohort of 11,703 patients was identified from years 2005 to 2017, with 342 (2.8%) incidences of WD within 30 days of operation. The final five-factor model included male gender [odds ratio (OR) = 2.5, p &lt; 0.001], surgical site infection (OR = 6.3, p &lt; 0.001), smoking (OR = 1.8, p &lt; 0.001), chronic obstructive pulmonary disease (COPD) (OR = 1.9, p &lt; 0.001), and weight class; morbidly obese patients had triple the odds of WD (OR = 2.9, p &lt; 0.001). The ROC analysis provided a C-statistic of 0.76 and calibration R<jats:sup>2<\/jats:sup> was 0.99. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The study yields a statistically robust and clinically beneficial five-factor model for estimation of WD incidence risk following RC, with good performance and excellent calibration. These factors may assist in identifying high-risk patients, providing preoperative counseling and thus leading to improvement in perioperative care. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562872211060570","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T06:49:49Z","timestamp":1638773389000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors for wound dehiscence following radical cystectomy: a prediction model"],"prefix":"10.1177","volume":"13","author":[{"given":"Ali A.","family":"Nasrallah","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Mansour","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassib F.","family":"Abou Heidar","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-4256","authenticated-orcid":false,"given":"Christian","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Balamand, Koura, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-894X","authenticated-orcid":false,"given":"Jad A.","family":"Najdi","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Tamim","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, American University of Beirut, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"El Hajj","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, American University of Beirut Medical Center, P.O. 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