{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:46:52Z","timestamp":1788173212857,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> Upper urinary tract urothelial carcinoma (UTUC) represents about 5\u201310% of all urothelial malignancies with an increasing incidence. The standard diagnostic tools for the detection of UTUC are cytology, computed tomography (CT) urography, and ureterorenoscopy (URS). No biomarker to be included in the daily clinical practice has yet been identified. The aim of our study was to evaluate the potential role of Xpert\u00ae Bladder-Cancer (BC)-Detection in the diagnosis of UTUC. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Eighty-two patients underwent 111 URS with Xpert\u00ae BC-Detection, cytology, or Urovysion\u00ae analysis of UT for suspicion of UTUC. Twenty-four cases were excluded from the analysis due to a non-diagnostic Xpert\u00ae BC-Detection, cytology, or Urovysion\u00ae. Samples were analyzed with upper tract (UT) urinary cytology, with Xpert\u00ae BC-Detection on UT urines, and with Urovysion\u00ae Fluorescence in situ hybridization (FISH) test. After urine collection, the patients underwent retrograde pyelography and\/or URS, and if positive a UT biopsy. The Xpert\u00ae BC-Detection was reported by the software as negative or positive [cut-off total Linear Discriminant Analysis (LDA) = 0.45]. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of cytology, Xpert\u00ae BC-Detection and Urovysion-FISH were calculated using URS and\/or histology results as reference. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> In all, 27 (31%) of 87 URS resulted positive, with 20 low-grade (LG) and 7 high-grade (HG) tumors. Overall sensitivity was 51.9% for cytology, 100% for Xpert\u00ae BC-Detection, and 92.6% for Urovysion. The sensitivity of cytology increased from 26% in LG to 100% in HG tumors. For Xpert\u00ae BC-Detection, sensitivity was 100% both in LG and in HG, and for Urovysion-FISH, it increased from 90% in LG to 100% in HG tumors. PPV was 82.4% for cytology, 35% for Xpert\u00ae BC-Detection, and 73.5% for Urovysion. NPV was 81.4% for cytology, 100% for Xpert\u00ae BC-Detection, and 96.2% for Urovysion. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> The excellent NPV of Xpert\u00ae BC-Detection allows to avoid unnecessary endoscopic exploration of the UT, reducing invasiveness and URS complications in the follow-up of UTUC. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17562872221090320","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:36:15Z","timestamp":1649856975000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Xpert\u00ae bladder cancer detection as a diagnostic tool in upper urinary tract urothelial carcinoma: preliminary results"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-9978","authenticated-orcid":false,"given":"Carolina","family":"D\u2019Elia","sequence":"first","affiliation":[{"name":"Department of Urology, Provincial Hospital of Bolzano, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-531X","authenticated-orcid":false,"given":"Emanuela","family":"Trenti","sequence":"additional","affiliation":[{"name":"Department of Urology, Bolzano Provincial Hospital, Lorenz B\u00f6hler St 5, Bolzano 39100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Urology, Provincial Hospital of Bolzano, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Pycha","sequence":"additional","affiliation":[{"name":"Cantonal Psychiatry Lucerne, Lucerne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Provincial Hospital of Bolzano, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Schwienbacher","sequence":"additional","affiliation":[{"name":"Department of Pathology, Provincial Hospital of Bolzano, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Hanspeter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Provincial Hospital of Bolzano, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Kafka","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Palermo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Latvia University, Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8888","authenticated-orcid":false,"given":"Giorgio Alfredo","family":"Spedicato","sequence":"additional","affiliation":[{"name":"Data Science Management, Unipol Group, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Holl","sequence":"additional","affiliation":[{"name":"Medical School, Sigmund Freud Private University, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Pycha","sequence":"additional","affiliation":[{"name":"Department of Urology, Provincial Hospital of Bolzano, Bolzano, Italy Medical School, Sigmund Freud Private University, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"bibr1-17562872221090320","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"bibr2-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24135"},{"key":"bibr3-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08818.x"},{"key":"bibr4-17562872221090320","unstructured":"Roupr\u00eat M, Babjuk M, Burger M, et al. EAU guidelines on upper urinary tract urothelial carcinoma. European Association of Urology, March 2020, http:\/\/uroweb.org\/guidelines\/compilations-of-all-guidelines\/"},{"key":"bibr5-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02875-8"},{"key":"bibr6-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.02.038"},{"key":"bibr7-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1185-1"},{"key":"bibr8-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22864-8"},{"key":"bibr9-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1309\/K5P2-4Y8B-7L5A-FAA9"},{"key":"bibr10-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.08.025"},{"key":"bibr11-17562872221090320","unstructured":"Boissier DR, Territo A, Gallioli A, et al. Feasibility of the Epicheck test in upper urinary tract tumour: interim analysis of a prospective trial. SC318 \u2013 EAU 2020 virtual, 17\u201320 July, https:\/\/nucleix.com>uploads>2020\/07>9"},{"key":"bibr12-17562872221090320","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1464-410X.2010.09899.x","volume":"108","author":"Messer J","year":"2011","journal-title":"BJU Int"},{"key":"bibr13-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01182-7"},{"key":"bibr14-17562872221090320","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.04.026"}],"container-title":["Therapeutic Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872221090320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562872221090320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872221090320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T19:09:42Z","timestamp":1740942582000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562872221090320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":14,"alternative-id":["10.1177\/17562872221090320"],"URL":"https:\/\/doi.org\/10.1177\/17562872221090320","relation":{},"ISSN":["1756-2872","1756-2880"],"issn-type":[{"value":"1756-2872","type":"print"},{"value":"1756-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"17562872221090320"}}