{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:30:33Z","timestamp":1777361433097,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Cytomegalovirus (CMV), an AIDS defining disease, has a high seroprevalence in the general population, while symptomatic infections occur mostly in immunocompromised individuals. Symptomatic CMV infections commonly include pneumonia, encephalitis, retinitis and colitis, while urinary tract involvement is a rare entity. We present a rare case of massive macroscopic haematuria due to CMV haemorrhagic cystitis in a 29-year-old woman in her second trimester of pregnancy. She was treated with intravenous Ganciclovir after initial resuscitation, and her symptoms promptly resolved. Timely diagnosis and treatment of symptomatic CMV infection is necessary to prevent associated morbidity, and this is especially significant during pregnancy in order to prevent foetal transmission. Both our patient and her baby remained symptom free at the 6-month follow-up post-delivery. Clinicians should have a high index of suspicion to biopsy the bladder urothelium of at-risk patients who present with haemorrhagic cystitis and have non-specific cystoscopy findings as histopathological analysis is the mainstay of diagnosing CMV-cystitis. <\/jats:p>","DOI":"10.1177\/17562872231159531","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T11:08:01Z","timestamp":1679483281000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytomegalovirus haemorrhagic cystitis in a pregnant patient with AIDS"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-0339","authenticated-orcid":false,"given":"Bernard","family":"Marais","sequence":"first","affiliation":[{"name":"Department of Urology, Frere Hospital, Walter Sisulu University, East London 5200, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-8891","authenticated-orcid":false,"given":"Veena","family":"John","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Frere Hospital, Walter Sisulu University, East London, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00ebtte","family":"Du Toit","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"},{"name":"National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Mbambo","sequence":"additional","affiliation":[{"name":"Department of Urology, Frere Hospital, Walter Sisulu University, East London, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-810X","authenticated-orcid":false,"given":"Jeff","family":"John","sequence":"additional","affiliation":[{"name":"Department of Urology, Frere Hospital, Walter Sisulu University, East London, South Africa"},{"name":"Department of Urology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"bibr1-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45449"},{"key":"bibr2-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"bibr3-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6156581"},{"key":"bibr4-17562872231159531","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.890945"},{"key":"bibr5-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.04.006"},{"key":"bibr6-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-007-0080-y"},{"key":"bibr7-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41515-1"},{"key":"bibr8-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1186\/s12301-020-00039-4"},{"key":"bibr9-17562872231159531","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.647209"},{"key":"bibr10-17562872231159531","first-page":"407","volume":"5","author":"Goncalvez J","year":"1995","journal-title":"Prog Urol"},{"key":"bibr11-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200002270-00034"},{"key":"bibr12-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"bibr13-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"bibr14-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31868-7"},{"key":"bibr15-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26039"},{"key":"bibr16-17562872231159531","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8101516"},{"key":"bibr17-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0501-z"},{"key":"bibr18-17562872231159531","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00268"},{"key":"bibr19-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441804"},{"key":"bibr20-17562872231159531","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"bibr21-17562872231159531","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020660"}],"container-title":["Therapeutic Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872231159531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562872231159531","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872231159531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T13:09:53Z","timestamp":1740920993000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562872231159531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":21,"alternative-id":["10.1177\/17562872231159531"],"URL":"https:\/\/doi.org\/10.1177\/17562872231159531","relation":{},"ISSN":["1756-2872","1756-2880"],"issn-type":[{"value":"1756-2872","type":"print"},{"value":"1756-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17562872231159531"}}