{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:23:42Z","timestamp":1793579022314,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate if prostate-specific antigen density (PSAD) predicts incidental prostate cancer (iPCa) in patients undergoing robot-assisted simple prostatectomy (RASP) for benign prostatic hyperplasia (BPH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 100 consecutive patients undergoing RASP for BPH were analyzed. Patients were stratified into low-risk and higher-risk groups based on their iPCa risk: 60 patients (PSAD\u2009\u2a7d\u20090.1\u2009ng\/mL\/cc) and 40 patients (PSAD\u2009&gt;\u20090.1\u2009ng\/mL\/cc), respectively. Outcomes included iPCa detection rates, preoperative imaging\/biopsy utilization, and postoperative complications. A multivariable logistic regression and an univariate linear regression analysis were conducted to assess whether PSAD can predict the incidence of PCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      iPCa was detected in 8% of cases. Five patients had &lt;5% tumor material in their final pathology (pT1a), while three had more than 5% (pT1b). iPCa was detected in eight patients, six with International Society of Urological Pathology (ISUP) 1 and 2 with ISUP\u2009&gt;\u20092. Patients with ISUP 1 were managed with active surveillance; only one chose robot-assisted radical prostatectomy, and the two with ISUP 2 and 3 opted for external radiation. Seven iPCa cases occurred in the low-PSAD group (11.7%), and one in the high-PSAD group (2.5%). In multivariate logistic regression, only a prior negative prostate biopsy was the strongest predictor of iPCa (odds ratio\u2009=\u20095.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01). PSAD\u2009&gt;\u20090.1\u2009ng\/mL\/cc was not associated (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.09). A univariate linear regression using PSAD as a continuous variable showed no significant association (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.27).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>PSAD, whether dichotomized (threshold of &gt;0.1\u2009ng\/mL\/cc) or continuous, didn\u2019t predict iPCa in men with large prostates. To optimize cancer detection, patients with large prostates may profit from prostate MRI before bladder outlet surgery, especially those with a history of prior prostate biopsy. Further research, including larger multicenter studies, is needed to validate our results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562872251386996","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:51:04Z","timestamp":1761990664000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidental prostate cancer: is prostate-specific antigen density a valid predictor? A case\u2013control study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-2187","authenticated-orcid":false,"given":"Mahmoud","family":"Farzat","sequence":"first","affiliation":[{"name":"Department of Robotic Urology, Diakonie Klinikum Siegen, Siegen, Germany"},{"name":"Department of Urology, Pediatric Urology and Andrology, Justus-Liebig University of Giessen, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2909-0797","authenticated-orcid":false,"given":"Florian M.","family":"Wagenlehner","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urology and Andrology, Justus-Liebig University of Giessen, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Benign prostatic hyperplasia","author":"Ng M","year":"2025","unstructured":"Ng M, Leslie SW, Baradhi KM. Benign prostatic hyperplasia. Treasure Island, FL: StatPearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC., 2025."},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.008"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-022-00616-4"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03168-1"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-024-05171-2"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-6051.24.05886-5"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04262-2"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.027"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.12.278"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24816"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24689"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.10.021"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_67_22"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-017-0024-7"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500957"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24078"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.05.005"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76786-9"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040297"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-017-2048-y"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.693684"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.4111\/kju.2012.53.6.391"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2021.0510"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.03.003"}],"container-title":["Therapeutic Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872251386996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562872251386996","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872251386996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:55:09Z","timestamp":1762350909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562872251386996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":26,"alternative-id":["10.1177\/17562872251386996"],"URL":"https:\/\/doi.org\/10.1177\/17562872251386996","relation":{},"ISSN":["1756-2872","1756-2880"],"issn-type":[{"value":"1756-2872","type":"print"},{"value":"1756-2880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"17562872251386996"}}