{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:57:24Z","timestamp":1762351044257,"version":"build-2065373602"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Upper tract urothelial carcinoma (UTUC) is a rare malignancy with a higher incidence in patients with end-stage renal disease (ESRD), particularly in regions with specific environmental risk factors. The diagnosis of UTUC in patients with ESRD remains challenging because of certain limitations inherent to current urine cytology techniques and imaging quality. Herein, we report the case of a 72-year-old woman with a history of bladder urothelial carcinoma and ESRD who was receiving regular hemodialysis and was incidentally diagnosed with high-grade multifocal UTUC following a nephrectomy procedure to treat symptomatic hydronephrosis. Despite routine cystoscopic surveillance and unremarkable cytological findings, progressive hydronephrosis was noted on serial imaging. Surgical intervention was performed as the patient\u2019s symptoms worsened progressively, after which pathological examination confirmed the presence of UTUC with renal parenchymal invasion. This case highlights the notion that UTUC should be considered as a differential diagnosis in patients with ESRD exhibiting symptomatic hydronephrosis of an unexplained etiology.<\/jats:p>","DOI":"10.1177\/17562872251393081","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:52:23Z","timestamp":1761990743000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Progression of hydronephrosis in end-stage renal disease as a potential indicator of underlying upper urinary tract tumors: a report of a rare case"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3334-1667","authenticated-orcid":false,"given":"Pai-Yu","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Rd., Banciao District, New Taipei City 220, Taiwan"},{"name":"Department of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiu-Dong","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan"},{"name":"Department of Nursing,College of Healthcare and Management, General Education Center, Asia Eastern University of Science and Technology, New Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-2070","authenticated-orcid":false,"given":"Chin-Fong","family":"Au","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Rd., Banciao District, New Taipei City 220, Taiwan"},{"name":"Program in Nutrition and food science, Fu Jen Catholic University, New Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-016-1928-x"},{"key":"e_1_3_4_3_2","article-title":"Chronic kidney disease is associated with upper tract urothelial carcinoma: a nationwide population-based cohort study in Taiwan","volume":"95","author":"Chen J-S","year":"2016","unstructured":"Chen J-S, Lu C-L, Huang L-C, et al. Chronic kidney disease is associated with upper tract urothelial carcinoma: a nationwide population-based cohort study in Taiwan. Medicine 2016; 95: e3255.","journal-title":"Medicine"},{"key":"e_1_3_4_4_2","first-page":"149750","article-title":"Increased upper and lower tract urothelial carcinoma in patients with end-stage renal disease: a nationwide cohort study in Taiwan during 1997\u20132008","volume":"2014","author":"Wang S-M","year":"2014","unstructured":"Wang S-M, Lai M-N, Chen P-C, et al. Increased upper and lower tract urothelial carcinoma in patients with end-stage renal disease: a nationwide cohort study in Taiwan during 1997\u20132008. Biomed Res Int 2014; 2014: 149750.","journal-title":"Biomed Res Int"},{"key":"e_1_3_4_5_2","first-page":"989458","article-title":"Upper tract urothelial carcinomas in patients with chronic kidney disease: relationship with diagnostic challenge","volume":"2014","author":"Wang L-J","year":"2014","unstructured":"Wang L-J, Lee S-Y, Teh BT, et al. Upper tract urothelial carcinomas in patients with chronic kidney disease: relationship with diagnostic challenge. Biomed Res Int 2014; 2014: 989458.","journal-title":"Biomed Res Int"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.11.19"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2023.11.011"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11111966"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194474"}],"container-title":["Therapeutic Advances in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872251393081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17562872251393081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17562872251393081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:54:31Z","timestamp":1762350871000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17562872251393081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":8,"alternative-id":["10.1177\/17562872251393081"],"URL":"https:\/\/doi.org\/10.1177\/17562872251393081","relation":{},"ISSN":["1756-2872","1756-2880"],"issn-type":[{"type":"print","value":"1756-2872"},{"type":"electronic","value":"1756-2880"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"17562872251393081"}}