{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:07:46Z","timestamp":1794046066077,"version":"4.8.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fournier\u2019s gangrene (FG) is a rapidly progressive necrotizing infection with high mortality. Early recognition of high-risk patients is critical for improving outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of the Inflammatory Burden Index (IBI)\u2014a composite marker derived from C-reactive protein, neutrophil, and lymphocyte counts\u2014for predicting mortality, intensive care requirements, and clinical course in FG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods:<\/jats:title>\n                    <jats:p>This retrospective cohort included 130 patients diagnosed with FG and treated at a tertiary referral center between 2015 and 2025. Demographic, clinical, and laboratory data were collected at admission. IBI was calculated using first-draw laboratory values. Primary outcomes were disease-specific mortality and intensive care unit (ICU) admission; secondary outcome was length of hospital stay. Univariable and multivariable logistic regression analyses were performed, and discriminatory capacity was evaluated using receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nonsurvivors exhibited significantly higher IBI values than survivors (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). On multivariable analysis, IBI independently predicted in-hospital mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.017), disease-specific mortality (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004), and ICU admission (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008). Higher IBI was also associated with prolonged hospitalization (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.012). Discriminative performance was acceptable, with an area under the curve of 0.757 for overall mortality and 0.856 for disease-specific mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Admission IBI is an independent predictor of mortality, ICU requirement, and hospital stay in FG. As a simple, cost-effective, and rapidly available biomarker, IBI may support early risk stratification and decision-making in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562872261430104","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:05:27Z","timestamp":1773914727000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of the inflammatory burden index for disease-specific mortality and intensive care need in Fournier\u2019s gangrene"],"prefix":"10.1177","volume":"18","author":[{"given":"Serkan","family":"Ozcan","sequence":"first","affiliation":[{"name":"Department of Urology, Izmir Katip Celebi University, Karabaglar, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2109-2015","authenticated-orcid":false,"given":"Enis Mert","family":"Yorulmaz","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Katip Celebi University, Karabaglar, Izmir 35360, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mertcan","family":"Dama","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Bayrakli City Hospital, Bayrakli, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursad","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Kose","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Katip Celebi University, Karabaglar, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacit Nuri","family":"Gorgel","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Katip Celebi University, Karabaglar, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigit","family":"Ak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Urology, Izmir Katip Celebi University, Karabaglar, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20161472"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.12.030"},{"key":"e_1_3_4_4_2","first-page":"122","article-title":"Fournier\u2019s gangrene: validation of the severity index","volume":"100","author":"Itaimi A","year":"2022","unstructured":"Itaimi A, Triki W, Abbassi I, et al. Fournier\u2019s gangrene: validation of the severity index. 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