{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T08:01:41Z","timestamp":1780128101273,"version":"3.54.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Urology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Robot-assisted cystectomy (RAC) is well established in the management of muscle-invasive or high-grade non-muscle invasive bladder cancer, but its role in benign disease is less well described. This case series represents the largest published experience of RAC for radiation cystitis and the largest series using an intracorporeal urinary diversion technique in this context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate perioperative outcomes and adverse events following RAC for benign indications, and to compare outcomes between patients with radiation cystitis and other benign conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Single-centre, retrospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients undergoing RAC for benign disease (2013\u20132024) were identified from a prospectively maintained database and electronic health records. Demographic, perioperative, and postoperative data were analysed using descriptive statistics. Comparative analyses were performed between patients undergoing cystectomy for radiation-related indications and those undergoing surgery for other benign indications using\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      tests, Fisher\u2019s exact tests, and Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      tests in R.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seventy patients (mean age 65\u2009years; range 23\u201396) underwent RAC. Indications included radiation cystitis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200934; 48.6%), other cystitis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200914; 20%), premalignant changes (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20099; 12.9%), refractory overactive bladder (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20098; 11.4%), neurogenic bladder (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20094; 5.7%), and Fowler\u2019s syndrome (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091; 1.4%). Intracorporeal ileal conduit diversion was performed in 57 cases (81%). Mean operative time was 334\u2009min (range 180\u2013540). Mean blood loss was 326\u2009ml (100\u20131250) in the radiation group and 300\u2009ml (100\u2013800) in other patients. Mean follow-up was 16\u2009months (1\u201358). No significant decline in renal function was observed at 1\u2009year in either group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.8). Complications occurred in 46 patients (66%) within 90\u2009days, with 34% graded Clavien-Dindo III or higher. Fifteen patients (21%) were readmitted within 30\u2009days, and 8 (11%) required further intervention. Limitations include the retrospective design.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RAC is safe and feasible for benign disease with no observed differences in outcomes between radiation cystitis and other indications in our cohort. Outcomes and complication rates observed are within the published ranges for malignancy-associated radical cystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17562872261451298","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:40:16Z","timestamp":1779885616000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Robot-assisted simple cystectomy for benign disease with medium-term follow-up: a case series"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-5249","authenticated-orcid":false,"given":"Martina","family":"Spazzapan","sequence":"first","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK"},{"name":"King\u2019s Clinical Academic Training Office, King\u2019s College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kam","sequence":"additional","affiliation":[{"name":"Sydney Medical School, University of Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Benn","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Lutfi","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Folkard","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Alain","family":"Furrer","sequence":"additional","affiliation":[{"name":"Department of Urology, Solothurner Spit\u00e4ler AG, Kantonsspital Olten, Olten, Switzerland"},{"name":"Department of Urology, Solothurner Spit\u00e4ler AG, B\u00fcrgerspital Solothurn, Solothurn, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Malde","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Thurairaja","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Nair","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prokar","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Sahai","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shamim","family":"Khan","sequence":"additional","affiliation":[{"name":"Urology Department, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.07.002"},{"key":"e_1_3_4_3_2","unstructured":"European Association of Urology. 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