{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:29:30Z","timestamp":1777458570111,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection Prevention"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Premature rupture of membranes (PROM) is one of the most common and important causes of premature births and peripartum mortality. Maternal antibiotic treatment affects the infantile prognosis. This study was conducted to compare the efficacy of Ampicillin and Cefotaxime administered for the parturients on neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A comparison between the effects of Cefotaxime and Ampicillin on infantile complications of PROM was done in this clinical trial. Two hundred and twenty parturients with PROM who needed antibiotic therapy were randomized in two groups of control (Ampicillin) and intervention (Cefotaxime) treatments. The maternal\/fetal statuses up to accouchement and the infants\u2019 status up to transfer to neonatal intensive care unit, death, or discharge from hospital were followed. The Apgar score, cardiac, respiratory and nervous systems, infection, immaturity, asphyxia, and mortality rates were compared in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The differences between the two groups were significant in: Apgar score min1 and min5, need for resuscitation, asphyxia, need for hospitalization, infection, and mortality rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Administration of Cefotaxime in parturients with PROM improved the Apgar scores and decreased respiratory complications, infection, asphyxia, mortality rate, and need for ICU hospitalization in infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17571774241261911","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T05:50:51Z","timestamp":1721541051000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal complications of premature rupture of membranes in mothers receiving cefotaxime and ampicillin: A randomized clinical trial"],"prefix":"10.1177","volume":"26","author":[{"given":"Hassan","family":"Boskabadi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafiseh","family":"Saghafi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed J","family":"Sayedi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Moradi","sequence":"additional","affiliation":[{"name":"Orthopedic Research Centre, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-9095","authenticated-orcid":false,"given":"Maryam","family":"Zakerihamidi","sequence":"additional","affiliation":[{"name":"Department of Midwifery, School of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"bibr1-17571774241261911","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000263888.69178.1f"},{"key":"bibr2-17571774241261911","first-page":"59","volume":"13","author":"Bahasadri S","year":"2006","journal-title":"Razi Journal of Medical Sciences"},{"key":"bibr19-17571774241261911","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.10.004"},{"key":"bibr3-17571774241261911","first-page":"77","volume":"7","author":"Boskabadi H","year":"2019","journal-title":"Journal of Pediatrics Review"},{"key":"bibr4-17571774241261911","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3889\/MJMS.1857-5773.2011.0177","volume":"4","author":"Boskabadi H","year":"2011","journal-title":"Macedonian Journal of Medical Sciences"},{"key":"bibr5-17571774241261911","first-page":"163","volume":"24","author":"Boskabadi H","year":"2014","journal-title":"Journal of Mazandaran University of Medical Sciences"},{"key":"bibr46-17571774241261911","unstructured":"Boskabadi H, Saghafi N, Najafi A. (2014b) Comparing the efficacy of cefotaxime and ampicillin on neonatal infection after premature rupture of membranes. The Iranian Journal of Obstetrics, Gynecology and Infertility 17(93): 1\u20139."},{"key":"bibr6-17571774241261911","first-page":"32","volume":"18","author":"Boskabadi H","year":"2016","journal-title":"Journal of Babol University of Medical Sciences"},{"key":"bibr8-17571774241261911","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.12.022"},{"issue":"5","key":"bibr21-17571774241261911","first-page":"349","volume":"66","author":"Ghazvini K","year":"2008","journal-title":"Tehran Univ Med J"},{"key":"bibr9-17571774241261911","first-page":"805","volume":"50","author":"Hamedi A","year":"2012","journal-title":"Acta Medica Iranica"},{"key":"bibr11-17571774241261911","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.07.489"},{"key":"bibr43-17571774241261911","doi-asserted-by":"publisher","DOI":"10.19082\/5434"},{"key":"bibr12-17571774241261911","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.972928"},{"key":"bibr13-17571774241261911","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01429-08"},{"key":"bibr14-17571774241261911","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17081"},{"key":"bibr15-17571774241261911","first-page":"659","volume":"73","author":"Medina TM","year":"2006","journal-title":"American Family Physician"},{"key":"bibr16-17571774241261911","doi-asserted-by":"crossref","unstructured":"Mercer BM, Goldenberg RL, Das AF, et al. (2003) What we have learned regarding antibiotic therapy for the reduction of infant morbidity after preterm premature rupture of the membranes. 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