{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:14:04Z","timestamp":1783430044385,"version":"3.54.6"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection Prevention"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transrectal prostate biopsy has raised concerns due to potential postbiopsy infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated infectious and non-infectious complication rates following transrectal biopsy without bowel preparation, using third-generation cephalosporin prophylaxis instead of resource-intensive targeted approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A single-centre retrospective study included biopsy-na\u00efve patients undergoing MRI\u2013ultrasound fusion-guided transrectal systematic and targeted prostate biopsies under local anaesthesia in an outpatient setting. All patients received third-generation cephalosporin prophylaxis, cefixime. The primary endpoint was the 30-day infectious complication rate, including fever, genitourinary infections, additional antibiotic prescriptions, unscheduled office\/emergency visits, hospitalisations, or sepsis. Secondary endpoints were non-infectious complications such as gross haematuria, rectal bleeding, or acute urinary retention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 336 cases were analysed. No cases of sepsis or positive blood cultures were observed. Infectious complications were uncommon, with fever \u226538\u00b0C occurring in 10 patients (2.9%), of whom 6 (1.8%) required hospitalisation. Localised infection, limited to epididymitis, was reported in 5 patients (1.5%) and was managed with additional antibiotics. Overall, 14 patients (4.2%) required unscheduled visits due to complications. Non-infectious complications were infrequent, with haematuria requiring bladder irrigation in 3 patients (0.9%) and acute urinary retention in 2 patients (0.6%). The median pain score during the procedure was 1.8 on a standardised scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Transrectal prostate biopsy using third-generation cephalosporin prophylaxis was associated with low infectious and non-infectious complication rates, with no sepsis cases reported. These findings highlight the procedure\u2019s safety and effectiveness, supporting its continued clinical use without the need for intensive prophylactic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17571774261449132","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:36:22Z","timestamp":1779374182000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Infectious and non-infectious complications associated with transrectal MRI-guided prostate biopsy using an alternative antibiotic regimen with oral cefixime"],"prefix":"10.1177","volume":"27","author":[{"given":"Wolff","family":"Laura","sequence":"first","affiliation":[{"name":"Academic Hospital \u2013 Heidelberg University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-7150","authenticated-orcid":false,"given":"Stankovic","family":"Mladen","sequence":"additional","affiliation":[{"name":"Academic Hospital \u2013 Heidelberg University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mendes","family":"Joao","sequence":"additional","affiliation":[{"name":"Academic Hospital \u2013 Heidelberg University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv133.982"},{"issue":"5","key":"e_1_3_6_3_1","first-page":"978","article-title":"Prostate biopsy track infection with escherichia coli: A prospective randomized trial of rectal cleansing methods","volume":"202","author":"Ding XF","year":"2019","unstructured":"Ding XF, Sweeney P, Klotz L, et al. (2019) Prostate biopsy track infection with escherichia coli: A prospective randomized trial of rectal cleansing methods. The Journal of Urology 202(5): 978\u2013982.","journal-title":"The Journal of Urology"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw265"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12536"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59050911"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.035"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.01.103"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.05.049"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae360"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003788"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.02.019"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.11.009"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0713-2"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.12.011"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2020.0072"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.17942"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac913"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.06.003"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.322"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit193"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1573-0"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006576.pub2"}],"container-title":["Journal of Infection Prevention"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17571774261449132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17571774261449132","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17571774261449132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:17:28Z","timestamp":1783426648000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17571774261449132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/17571774261449132"],"URL":"https:\/\/doi.org\/10.1177\/17571774261449132","relation":{},"ISSN":["1757-1774","1757-1782"],"issn-type":[{"value":"1757-1774","type":"print"},{"value":"1757-1782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}