{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:23:27Z","timestamp":1789457007702,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Shoulder &amp; Elbow"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cutibacterium acnes is a recognized culprit for implant-associated infections, but positive cultures do not always indicate clinically relevant infection. Studies have shown a correlation between the \u03b2-hemolytic phenotype of C. acnes and its infectious capacity, but correlation with genetic phylotype has not been performed in literature. The purpose of this study is to evaluate \u03b2-hemolysis phenotype, genetic phylotype, and mid-term clinical outcomes of C. acnes isolated from orthopedic surgical sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-four C. acnes isolates previously obtained from surgical wounds of patients undergoing hip, knee, shoulder, or spine implant removal were re-cultured. There were 21 females and 33 males with an average age of 59 years (range, 18\u201384). Twenty-four were from clinically infected sites whereas 30 were considered contaminants. De\u00a0novo \u03b2-hemolysis was analyzed and a retrospective chart review was performed to evaluate clinical outcomes at 7.1 years (range, 0.1\u201312.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On Brucella agar with 5% rabbit blood, 46% of contaminant and 43% of infectious isolates were hemolytic. Type II phylotype was significantly more nonhemolytic regardless of infectious or contaminant status (p\u2009&lt;\u20090.05). Type 1B correlated with a hemolytic-infectious phenotype and Type 1A with a hemolytic-contaminant phenotype but was not statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The \u03b2-hemolytic profile of C. acnes did not correlate with phylotype or clinically relevant orthopedic infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1758573219865884","type":"journal-article","created":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T01:58:27Z","timestamp":1565402307000},"page":"390-398","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlation between hemolytic profile and phylotype of\n                    <i>Cutibacterium acnes<\/i>\n                    (formerly\n                    <i>Propionibacterium acnes<\/i>\n                    ) and orthopedic implant infection"],"prefix":"10.1177","volume":"12","author":[{"given":"Julia","family":"Lee","sequence":"first","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryl E","family":"Greenwood Quaintance","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey N","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave R","family":"Shukla","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H","family":"Cofield","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Sperling","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-3247","authenticated-orcid":false,"given":"Joaquin","family":"Sanchez-Sotelo","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"bibr1-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2011.08.067"},{"key":"bibr2-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-008-0226-3"},{"key":"bibr3-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2009.01.023"},{"key":"bibr4-1758573219865884","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.00881"},{"key":"bibr5-1758573219865884","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.15.00568"},{"key":"bibr6-1758573219865884","first-page":"E93","volume":"43","author":"Nodzo SR","year":"2014","journal-title":"Am J Orthop"},{"key":"bibr7-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.326-334.2005"},{"key":"bibr8-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.01.024"},{"key":"bibr9-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1556\/1886.2016.00040"},{"key":"bibr10-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1038\/srep39491"},{"key":"bibr11-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012277"},{"key":"bibr12-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061588"},{"key":"bibr13-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01686-08"},{"key":"bibr14-1758573219865884","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis966"},{"key":"bibr15-1758573219865884","unstructured":"Microbank Worldwide Performance Portfolio. Bacterial & Fungal Storage System:\n                      Pro-Lab Diagnostics\n                      , 2011."},{"key":"bibr16-1758573219865884","volume-title":"Wadsworth-KTL anaerobic bacteriology manual","author":"Jousimies-Somer HSP","year":"2002","edition":"6"},{"key":"bibr17-1758573219865884","volume-title":"Handbook of microbiological media","author":"Atlas R","year":"1997","edition":"2"},{"key":"bibr18-1758573219865884","unstructured":"Appleman MD, Citron DM, O\u2019Kelly J, et\u00a0al,\n                      Principles and procedures for detection of anaerobes in clinical specimens; approved guideline.\n                      CLSI document M56-A. 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