{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:33:04Z","timestamp":1777876384133,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T00:00:00Z","timestamp":1477094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Many patients with solid tumours or nonmyeloid haematopoietic tumours develop symptomatic anaemia, which has a major impact on quality of life (QoL). The efficacy of erythropoiesis-stimulating agents (ESAs) in improving QoL and reducing blood transfusions has been widely demonstrated. Binocrit\u00ae (biosimilar epoetin alfa) is an ESA indicated in the European Union for treating chemotherapy-induced anaemia. The aim of this study was to investigate the effect of Binocrit\u00ae on haemoglobin (Hb) levels in anaemic cancer patients in Italian clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The ANEMONE study was a national, longitudinal, retrospective, multicentre observational study. Patients had to be 18 years or older, with a solid tumour or non-Hodgkin\u2019s lymphoma, Hodgkin\u2019s disease or multiple myeloma, receiving chemotherapy, and treated with Binocrit\u00ae to manage chemotherapy-induced anaemia. The primary outcomes were the proportion of patients with a Hb increase \u2a7e1 g\/dl during the first 4 weeks and with a Hb increase \u2a7e2 g\/dl during the first 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 245 patients were enrolled and 215 patients were evaluable for statistical analysis. In the first 4 weeks, 49.3% of patients showed an increase in Hb of \u2a7e1 g\/dl: 45.5% in patients with solid tumours and 52.1% in patients with haematological malignancies. In the first 12 weeks, 51.6% of patients showed an increase in Hb of \u2a7e2 g\/dl (48.4% solid tumours, 54.2% haematological diseases). Treatment with Binocrit\u00ae was well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results confirm the effectiveness and safety of Binocrit\u00ae for chemotherapy-induced anaemia in routine practice in patients with solid tumours, lymphoma and myeloma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1758834016670554","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T23:58:18Z","timestamp":1477094298000},"page":"22-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Management of anaemia in oncohaematological patients treated with biosimilar epoetin alfa: results of an Italian observational, retrospective study"],"prefix":"10.1177","volume":"9","author":[{"given":"Giovanni","family":"Rosti","sequence":"first","affiliation":[{"name":"Oncologia, Policlinico San Matteo IRCCS, Pavia, Via Scarpa 1, 31100 Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Petrini","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria Pisana, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Bosi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Careggi Hospital and University of Florence, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Galieni","sequence":"additional","affiliation":[{"name":"Ospedale C. e G. Mazzoni, Ascoli Piceno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Bernardi","sequence":"additional","affiliation":[{"name":"ULSS 10 \u2018Veneto Orientale\u2019, San Don\u00e0 di Piave, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Giglio","sequence":"additional","affiliation":[{"name":"Ospedale Cardarelli, Campobasso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Dorotea","sequence":"additional","affiliation":[{"name":"Ospedale Riuniti Padova Sud, Monselice, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunangelo","family":"Falini","sequence":"additional","affiliation":[{"name":"Ospedale Santa Maria della Misericordia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Scelzi","sequence":"additional","affiliation":[{"name":"Ospedale di Castelfranco Veneto (ULSS), Castelfranco Veneto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Veltri","sequence":"additional","affiliation":[{"name":"Ospedale S. Maria Goretti, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Castelli","sequence":"additional","affiliation":[{"name":"Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Longagnani","sequence":"additional","affiliation":[{"name":"MediNeos surl, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Raggi","sequence":"additional","affiliation":[{"name":"Sandoz S.p.A., Origgio, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Versilia Azienda ULSS 12, Lido di Camaiore, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,22]]},"reference":[{"key":"bibr1-1758834016670554","doi-asserted-by":"publisher","DOI":"10.5639\/gabij.2013.0202.023"},{"key":"bibr2-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0311-2"},{"key":"bibr3-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu579"},{"key":"bibr4-1758834016670554","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.43"},{"key":"bibr5-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2012.712681"},{"key":"bibr6-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03532.x"},{"key":"bibr7-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70365-1"},{"key":"bibr8-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.8.914"},{"key":"bibr9-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0451"},{"key":"bibr10-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.10.014"},{"key":"bibr11-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.04.003"},{"key":"bibr12-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh235"},{"key":"bibr13-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-011-0196-3"},{"key":"bibr14-1758834016670554","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0069"},{"key":"bibr15-1758834016670554","doi-asserted-by":"publisher","DOI":"10.2217\/fon.12.39."},{"key":"bibr16-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04129.x"},{"key":"bibr17-1758834016670554","first-page":"951","volume":"27","author":"Loney M.","year":"2000","journal-title":"Oncol Nurs Forum"},{"key":"bibr18-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2189-0"},{"key":"bibr19-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.02.003"},{"key":"bibr20-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.019"},{"key":"bibr21-1758834016670554","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1767"},{"key":"bibr22-1758834016670554","first-page":"43","volume":"5","author":"Rodriguez Garzotto A.","year":"2014","journal-title":"J Blood Med"},{"key":"bibr23-1758834016670554","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/0959-8049(95)96128-Z","volume":"31","author":"Skillings J.","year":"1995","journal-title":"Eur J Cancer"},{"key":"bibr24-1758834016670554","first-page":"168","volume":"32","author":"Weigang-K\u00f6hler K.","year":"2009","journal-title":"Onkologie"}],"container-title":["Therapeutic Advances in Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1758834016670554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1758834016670554","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1758834016670554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:21:39Z","timestamp":1777587699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1758834016670554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,22]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/1758834016670554"],"URL":"https:\/\/doi.org\/10.1177\/1758834016670554","relation":{},"ISSN":["1758-8359","1758-8359"],"issn-type":[{"value":"1758-8359","type":"print"},{"value":"1758-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,22]]}}}