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The aim of this review is to discuss the issue of cisplatin-induced nephrotoxicity in the elderly. Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, and survival time may be decreased. Following cisplatin treatment of elderly patients, tubulointerstitial injuries will be significantly aggravated based on their original age, both for acute injuries due to cell necrosis and exfoliation and chronic injuries due to interstitial fibrosis, tubular atrophy, and dilatation. The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic kidney disease (CKD), cardiovascular disease, and diabetes mellitus; increased use of combined drugs [especially non-steroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitor and angiotensin receptor blockers (ACEI\/ARB), and antibiotics]; decreased clearance of cisplatin; and high plasma ultrafilterable cisplatin. Considering hemodynamic stability and water balance, short duration and low volume hydration may be more suitable for treating elderly people. With the increasing popularity of low-dose daily\/weekly regimens, we do not recommend routine diuretic treatment for elderly patients. We recommend using a less nephrotoxic platinum if large doses of cisplatin (100mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) are needed.\n                  <\/jats:p>","DOI":"10.1177\/1758835920923430","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T01:23:52Z","timestamp":1589851432000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":101,"title":["Cisplatin-induced renal toxicity in elderly people"],"prefix":"10.1177","volume":"12","author":[{"given":"ZhiYu","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China"},{"name":"Department of Nephrology, The Fourth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuangYan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing, 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiJun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The Fourth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangMei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"bibr1-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"bibr2-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197704)39:4<1357::AID-CNCR2820390402>3.0.CO;2-C"},{"key":"bibr3-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.60.7481"},{"key":"bibr4-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0392-z"},{"key":"bibr5-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971001)80:7<1273::AID-CNCR13>3.0.CO;2-4"},{"key":"bibr6-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70275-6"},{"key":"bibr7-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12287"},{"key":"bibr8-1758835920923430","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8983"},{"key":"bibr9-1758835920923430","unstructured":"National Institutes of Health. 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