{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:53:45Z","timestamp":1789077225560,"version":"build-2803163510"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anemia is commonly encountered in cancer patients receiving active chemotherapy. Due to adverse events and presumed negative effects on disease-progression and survival, erythropoiesis-stimulating agents are not frequently used. In this study, we assess the efficacy and safety of intravenous ferric carboxymaltose (FCM) to treat cancer-induced anemia (CIA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>We recruited adult cancer patients on active chemotherapy with a hemoglobin (Hb) level \u2a7d11.0\u2009g\/dL. Based on serum ferritin (sFr) and transferrin saturation (TSAT), patients were divided into 3 groups: group I (absolute iron deficiency, n\u2009=\u200926) with sFr\u2009&lt;\u200930\u2009ng\/mL and TSAT\u2009&lt;\u200920%; group II (functional iron deficiency, n\u2009=\u200924) with sFr 30\u2013800\u2009ng\/mL and TSAT\u2009&lt;\u200920%; and patients with TSAT\u2009\u2a7e\u200920% were placed in group III as \u201cothers\u201d ( n\u2009=\u200934). All patients were treated with intravenous FCM. Serum hepcidin and C-reactive protein were used as biomarkers to predict response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 84 patients with a median age (SD) of 53.8 (10.6) were recruited. Baseline median Hb level was 10.2 (range: 8.3\u201311.0) gm\/dL. At week 12, there was a significant increment in Hb level for patients in groups I and II (median increment: 2.35 and 1.5\u2009gm\/dL, respectively), with limited response observed in group III, and most of the increment noted as early as week 3 (\u2a7e1.0\u2009g\/dL). Responders tended to have lower levels of hepcidin. No clinically significant adverse events were reported; however, asymptomatic hypophosphatemia was observed in 39 (46.4%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Intravenous FCM is a safe and effective treatment option for the management of a subgroup of patients with CIA. The study was registered at ClinicalTrials.gov [Identifier: NCT04246021]<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1758835920953292","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T03:23:07Z","timestamp":1599621787000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of anemia in cancer patients undergoing chemotherapy with intravenous ferric carboxymaltose without erythropoiesis-stimulating agents"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2833-6051","authenticated-orcid":false,"given":"Hikmat","family":"Abdel-Razeq","sequence":"first","affiliation":[{"name":"Department of Medical oncology, King Hussein Cancer Center, 202 Queen Rania Al-Abdullah, Amman, 11941, Jordan"},{"name":"School of Medicine, University of Jordan, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1052-9093","authenticated-orcid":false,"given":"Salwa S.","family":"Saadeh","sequence":"additional","affiliation":[{"name":"Department of Medical oncology, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razan","family":"Malhis","sequence":"additional","affiliation":[{"name":"Department of Medical oncology, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Yasser","sequence":"additional","affiliation":[{"name":"Department of Medical oncology, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Abdulelah","sequence":"additional","affiliation":[{"name":"Department of Medical oncology, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Eljaber","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Kleib","sequence":"additional","affiliation":[{"name":"Department of Nursing, King Hussein Cancer Center, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouba","family":"Ismael","sequence":"additional","affiliation":[{"name":"Office of Scientific Affairs and Research, King Hussein Cancer Center, Amman, 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