{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:35:01Z","timestamp":1777876501315,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aims to compare the outcomes of COVID-19-positive disease in patients with a history of cancer to those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively collected clinical data and outcomes of COVID-19 positive cancer patients treated consecutively in five North London hospitals (cohort A). Outcomes recorded included time interval between most recent anti-cancer treatment and admission, severe outcome [a composite endpoint of intensive care unit (ITU) admission, ventilation and\/or death] and mortality. Outcomes were compared with consecutively admitted COVID-19 positive patients, without a history of cancer (cohort B), treated at the primary centre during the same time period (1 March\u201330 April 2020). Patients were matched for age, gender and comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The median age in both cohorts was 74\u2009years, with 67% male, and comprised of 30 patients with cancer, and 90 without (1:3 ratio). For cohort B, 579 patients without a history of cancer and consecutively admitted were screened from the primary London hospital, 105 were COVID-19 positive and 90 were matched and included. Excluding cancer, both cohorts had a median of two comorbidities. The odds ratio (OR) for mortality, comparing patients with cancer to those without, was 1.05 [95% confidence interval (CI) 0.4\u20132.5], and severe outcome (OR 0.89, 95% CI 0.4\u20132.0) suggesting no increased risk of death or a severe outcome in patients with cancer. Cancer patients who received systemic treatment within 28\u2009days had an OR for mortality of 4.05 (95% CI 0.68\u201323.95), p\u2009=\u20090.12. On presentation anaemia, hypokalaemia, hypoalbuminaemia and hypoproteinaemia were identified predominantly in cohort A. Median duration of admission was 8 days for cancer patients and 7\u2009days for non-cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A diagnosis of cancer does not appear to increase the risk of death or a severe outcome in COVID-19 patients with cancer compared with those without cancer. If a second spike of virus strikes, rational decision making is required to ensure optimal cancer care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1758835920956803","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T04:02:32Z","timestamp":1600056152000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Outcomes of the 2019 novel coronavirus in patients with or without a history of cancer: a multi-centre North London experience"],"prefix":"10.1177","volume":"12","author":[{"given":"Nalinie","family":"Joharatnam-Hogan","sequence":"first","affiliation":[{"name":"MRC CTU UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hochhauser","sequence":"additional","affiliation":[{"name":"University College London Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Keen","family":"Shiu","sequence":"additional","affiliation":[{"name":"University College London Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Rush","sequence":"additional","affiliation":[{"name":"University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-4051","authenticated-orcid":false,"given":"Valerie","family":"Crolley","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cancer Research UK and UCL Cancer Trials Centre, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Sharma","sequence":"additional","affiliation":[{"name":"Mount Vernon Hospital, Northwood, Middlesex, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aun","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Whittington Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Anwar","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital, Harlow, Essex, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Vasdev","sequence":"additional","affiliation":[{"name":"Lister Hospital (East and North Herts NHS Trust), Stevenage, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Royal Free Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganna","family":"Kantser","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aramita","family":"Saha","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fharat","family":"Raja","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bridgewater","sequence":"additional","affiliation":[{"name":"University College London Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurum","family":"Khan","sequence":"additional","affiliation":[{"name":"Gastrointestinal Oncology Service and Cancer of Unknown Primary Service; University College London Hospital NHS Foundation Trust, UCL Cancer Institute and North Middlesex University Hospital; GI Cancer Lead North London Cancer Research Netword, and Oncology Research Lead North Middlesex University Hospital, 250 Euston Rd, Kings Cross, London, NW1 2PG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"bibr1-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"bibr2-1758835920956803","unstructured":"World Health Organisation. Rolling Updates on Coronavirus Disease (COVID-19), https:\/\/wwwwhoint\/emergencies\/diseases\/novel-coronavirus-2019\/events-as-they-happen (2020, accessed 16 March 2020)."},{"key":"bibr3-1758835920956803","unstructured":"Department of Health and Social Care and Public Health England. Number of coronavirus (COVID-19) cases and risk in the UK, https:\/\/wwwgovuk\/ (2020, accessed 16 March 2020)."},{"key":"bibr4-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"bibr5-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"bibr6-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30558-4"},{"key":"bibr7-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"bibr8-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30096-6"},{"key":"bibr9-1758835920956803","first-page":"557","volume":"2020","author":"Desai A","journal-title":"JCO Glob Oncol"},{"key":"bibr10-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30150-9"},{"key":"bibr11-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30149-2"},{"key":"bibr12-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.296"},{"key":"bibr13-1758835920956803","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1158\/2159-8290.CD-20-0422","volume":"10","author":"Dai M","year":"2020","journal-title":"Cancer Discov"},{"key":"bibr14-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.003"},{"key":"bibr15-1758835920956803","unstructured":"National Institute for Health and Care Excellence. COVID-19 rapid guideline: delivery of systemic anticancer treatments, https:\/\/wwwniceorguk\/guidance\/ng161\/chapter\/6-Prioritising-systemic-anticancer-treatments (accessed 7 May 2020)."},{"key":"bibr16-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30165-X"},{"key":"bibr17-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa282."},{"key":"bibr18-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"bibr19-1758835920956803","unstructured":"Department of Health and Social Care and Public Health England. Next stage of expanded coronavirus (COVID-19) public information campaign launches, https:\/\/wwwgovuk\/ (2020, accessed 17 March 2020)."},{"key":"bibr20-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30217-5"},{"key":"bibr21-1758835920956803","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2011595"}],"container-title":["Therapeutic Advances in Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1758835920956803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1758835920956803","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1758835920956803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:24:53Z","timestamp":1777587893000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1758835920956803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":21,"alternative-id":["10.1177\/1758835920956803"],"URL":"https:\/\/doi.org\/10.1177\/1758835920956803","relation":{},"ISSN":["1758-8359","1758-8359"],"issn-type":[{"value":"1758-8359","type":"print"},{"value":"1758-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1758835920956803"}}