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These immunoconjugates encompass the general tendency towards precision medicine and avert the systemic toxicities of conventional chemotherapy, accomplishing an improved therapeutic index. Cumulative experience acquired from first-generation ADCs offers new perspectives to these promising therapeutic modalities for various hematological and solid cancers and propels their clinical development in a faster-than-ever pace, as indicated by the approval of four novel ADCs during the last year. This paper aims to provide an up-to-date overview of the eight ADCs approved by the US Food and Drug Administration and their current indications in oncological practice. Starting from their bio-pharmaceutical background, we track their clinical evolution, with an emphasis on the pivotal trials that led to their commercial release. Late-stage studies examining these eight ADCs in other-than-approved settings as well as the investigation of potential new candidates are also reviewed. In the close future, more data are expected to expand ADCs\u2019 oncological utility and to further reshape their role in cancer therapeutics.<\/jats:p>","DOI":"10.1177\/1758835920962997","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T02:04:29Z","timestamp":1601863469000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["An overview of antibody\u2013drug conjugates in oncological practice"],"prefix":"10.1177","volume":"12","author":[{"given":"Charalampos","family":"Theocharopoulos","sequence":"first","affiliation":[{"name":"First Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Laiko General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis-Petros","family":"Lialios","sequence":"additional","affiliation":[{"name":"First Department of Medicine, National and Kapodistrian 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