{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:37:34Z","timestamp":1777876654414,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111-2926-I-075-501-G"],"award-info":[{"award-number":["111-2926-I-075-501-G"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Recently, immune checkpoint inhibitors (ICIs) have become the standard treatment option for patients with lung cancer, including small cell lung cancer (SCLC). ICI-induced neurological immune-related adverse events are rare and exhibit diverse clinical manifestations, often leading to missed or delayed diagnosis. Herein, we report the case of a patient with extensive-stage SCLC who received atezolizumab with etoposide\/platinum and gradually developed neurological symptoms after three cycles of chemoimmunotherapy. Subsequently, the patient received a diagnosis of subacute immune-related cerebellar ataxia and was treated successfully with pulse steroid therapy. The patient exhibited almost complete remission of neurological symptoms and had progression-free survival for &gt;24 months.<\/jats:p>","DOI":"10.1177\/17588359231192398","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T05:59:02Z","timestamp":1693461542000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Atezolizumab-induced subacute cerebellar ataxia in a patient with extensive-stage small cell lung cancer"],"prefix":"10.1177","volume":"15","author":[{"given":"Chun-Chia","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Hua","family":"Tseng","sequence":"additional","affiliation":[{"name":"Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Lin","family":"Lai","sequence":"additional","affiliation":[{"name":"Neurological Institute, Taipei Veterans General Hospital, Taipei"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-0669","authenticated-orcid":false,"given":"Chi-Lu","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei 112"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"bibr1-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.11.005"},{"key":"bibr2-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15624"},{"key":"bibr3-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-018-0987-5"},{"key":"bibr4-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-021-10026-3"},{"key":"bibr5-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1655013"},{"key":"bibr6-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-018-3465-4"},{"key":"bibr7-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005781"},{"key":"bibr8-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.03.006"},{"key":"bibr9-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.05.042"},{"key":"bibr10-17588359231192398","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-231520"}],"container-title":["Therapeutic Advances in Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17588359231192398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17588359231192398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17588359231192398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:28:58Z","timestamp":1777588138000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17588359231192398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"alternative-id":["10.1177\/17588359231192398"],"URL":"https:\/\/doi.org\/10.1177\/17588359231192398","relation":{},"ISSN":["1758-8359","1758-8359"],"issn-type":[{"value":"1758-8359","type":"print"},{"value":"1758-8359","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17588359231192398"}}