{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:37:54Z","timestamp":1777876674101,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To date, limited evidence exists on the impact of COVID-19 in patients with soft tissue sarcoma (STS), nor about the impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in this specific population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We described COVID-19 morbidity and mortality among patients with STS across \u2018Omicron\u2019 (15 December 2021\u201331 January 2022), \u2018Pre-vaccination\u2019 (27 February 2020\u201330 November 2020), and \u2018Alpha-Delta\u2019 phase (01 December 2020\u201314 December 2021) using OnCovid registry participants (NCT04393974). Case fatality rate at 28 days (CFR\n                      <jats:sub>28<\/jats:sub>\n                      ) and COVID-19 severity were also described according to the SARS-CoV-2 vaccination status, while the impact of the receipt of cytotoxic chemotherapy within 4 weeks prior to COVID-19 on clinical outcomes was assessed with Inverse Probability of Treatment Weighting (IPTW) models adjusted for possible confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of 3820 patients, 97 patients with STS were included. The median age at COVID-19 diagnosis was 56 years (range: 18\u201392), with 65 patients (67%) aged &lt; 65 years and most patients had a low comorbidity burden (65, 67.0%). The most frequent primary tumor sites were the abdomen (56.7%) and the gynecological tract (12.4%). In total, 36 (37.1%) patients were on cytotoxic chemotherapy within 4 weeks prior to COVID-19. The overall CFR\n                      <jats:sub>28<\/jats:sub>\n                      was 25.8%, with 38% oxygen therapy requirement, 34% rate of complications, and 32.3% of hospitalizations due to COVID-19. CFR\n                      <jats:sub>28<\/jats:sub>\n                      (29.5%, 21.4%, and 12.5%) and all indicators of COVID-19 severity demonstrated a trend toward a numerical improvement across the pandemic phases. Similarly, vaccinated patients demonstrated numerically improved CFR\n                      <jats:sub>28<\/jats:sub>\n                      (16.7% versus 27.7%) and COVID-19 morbidity compared with unvaccinated patients. Patients who were on chemotherapy experienced comparable CFR\n                      <jats:sub>28<\/jats:sub>\n                      (19.4% versus 26.0%, p = 0.4803), hospitalizations (50.0% versus 44.4%, p = 0.6883), complication rates (30.6% versus 34.0%, p = 0.7381), and oxygen therapy requirement (28.1% versus 40.0%, p = 0.2755) compared to those who were not on anticancer therapy at COVID-19, findings further confirmed by the IPTW-fitted multivariable analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this study, we demonstrate an improvement in COVID-19 outcomes in patients with STS over time. Recent exposure to chemotherapy does not impact COVID-19 morbidity and mortality and SARS-CoV-2 vaccination confers protection against adverse outcomes from COVID-19 in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359231225028","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T08:07:46Z","timestamp":1705565266000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry"],"prefix":"10.1177","volume":"16","author":[{"given":"Bruno","family":"Vincenzi","sequence":"first","affiliation":[{"name":"Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy"},{"name":"Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-5735","authenticated-orcid":false,"given":"Alessio","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy"},{"name":"Department of Surgery and Cancer, Imperial College of London, Hammersmith Hospital Campus, Du Cane Road, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0219-119X","authenticated-orcid":false,"given":"Alessandro","family":"Mazzocca","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy"},{"name":"Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Orlando","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy"},{"name":"Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Romandini","sequence":"additional","affiliation":[{"name":"Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy"},{"name":"Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-1950","authenticated-orcid":false,"given":"Juan","family":"Aguilar-Company","sequence":"additional","affiliation":[{"name":"Medical Oncology, Vall d\u2019Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain"},{"name":"Infectious Diseases, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Ruiz-Camps","sequence":"additional","affiliation":[{"name":"Medical Oncology, Vall d\u2019Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain"},{"name":"Infectious Diseases, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Valverde Morales","sequence":"additional","affiliation":[{"name":"Medical Oncology, Vall d\u2019Hebron University Hospital and Institute of Oncology (VHIO), IOB-Quiron, UVic-UCC, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simeon","family":"Eremiev-Eremiev","sequence":"additional","affiliation":[{"name":"Medical Oncology, Vall d\u2019Hebron University Hospital and Institute of Oncology (VHIO), 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X.","family":"Lee","sequence":"additional","affiliation":[{"name":"Cancer Division, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cian","family":"Murphy","sequence":"additional","affiliation":[{"name":"Cancer Division, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Belessiotis","sequence":"additional","affiliation":[{"name":"Cancer Division, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Medical Oncology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Pommeret","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Saclay, Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Loizidou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Internal Medicine, Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Translational Medicine, University of Piemonte Orientale and Ospedale Maggiore della Carit\u00e0 Hospital, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino M.","family":"Dettorre","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Spedali Civili, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-4897","authenticated-orcid":false,"given":"Marco","family":"Tucci","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Department of Interdisciplinary Medicine (DIM), University of Bari \u2018Aldo Moro\u2019, Bari, Italy"},{"name":"IRCCS, Istituto Tumori Giovanni Paolo II, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia A. 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