{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:56:36Z","timestamp":1791618996752,"version":"4.3.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018731","name":"Jiangsu Hengrui Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chemotherapy-induced thrombocytopenia (CIT) increases the risk of bleeding, necessitates chemotherapy dose reductions and delays, and negatively impacts prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy and safety of hetrombopag for the management of CIT in patients with advanced solid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A multicenter, randomized, double-blind, placebo-controlled, phase II study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients with advanced solid tumors who experienced a chemotherapy delay of \u2a7e7\u2009days due to thrombocytopenia (platelet count &lt;75\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) were randomly assigned (1:1) to receive oral hetrombopag at an initial dose of 7.5\u2009mg once daily or a matching placebo. The primary endpoint was the proportion of treatment responders, defined as patients resuming chemotherapy within 14\u2009days (platelet count \u2a7e100\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) and not requiring a chemotherapy dose reduction of \u2a7e15% or a delay of \u2a7e4\u2009days or rescue therapy for two consecutive cycles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Between 9 October 2021 and 5 May 2022, 60 patients were randomized, with 59 receiving \u2a7e1 dose of assigned treatment (hetrombopag\/placebo arm, n\u2009=\u200928\/31). The proportion of treatment responders was significantly higher in the hetrombopag arm than in the placebo arm [60.7% (17\/28) versus 12.9% (4\/31); difference of proportion: 47.6% (95% confidence interval (CI): 26.0\u201369.3); odds ratio\u2009=\u200910.44 (95% CI: 2.82\u201338.65); p value (nominal) based on the Cochran\u2013Mantel\u2013Haenszel: &lt;0.001)]. During the double-blind treatment period, grade 3 or higher adverse events (AEs) occurred in 35.7% (10\/28) of patients with hetrombopag and 38.7% (12\/31) of patients on placebo. The most common grade 3 or higher AEs were decreased neutrophil count [35.7% (10\/28) versus 35.5% (11\/31)] and decreased white blood cell count [17.9% (5\/28) versus 19.4% (6\/31)]. Serious AEs were reported in 3.6% (1\/28) of patients with hetrombopag and 9.7% (3\/31) of patients with placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hetrombopag is an effective and well-tolerated alternative for managing CIT in patients with solid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT03976882.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359241260985","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T01:06:44Z","timestamp":1718413604000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Hetrombopag for the management of chemotherapy-induced thrombocytopenia in patients with advanced solid tumors: a multicenter, randomized, double-blind, placebo-controlled, phase II study"],"prefix":"10.1177","volume":"16","author":[{"given":"Shukui","family":"Qin","sequence":"first","affiliation":[{"name":"GI Cancer Center, Nanjing Tianyinshan Hospital, China Pharmaceutical, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Wang","sequence":"additional","affiliation":[{"name":"First Gastroenterology Ward, Shanxi Provincial Cancer Hospital, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Henan Cancer Hospital, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiangyang Central Hospital, Xiangyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Anhui Provincial Hospital, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Subei People\u2019s Hospital of Jiangsu Province, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sichuan Cancer Hospital and Institute, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shaanxi Provincial Cancer Hospital, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Nanyang Medical College, Nanyang, 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