{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:44:08Z","timestamp":1784691848290,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"national cancer institute","doi-asserted-by":"publisher","award":["CA023100"],"award-info":[{"award-number":["CA023100"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["5U01CA180888-08"],"award-info":[{"award-number":["5U01CA180888-08"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["5UG1CA233198-05"],"award-info":[{"award-number":["5UG1CA233198-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joan and Irwin Jacobs Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The prognostic implications of tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are poorly studied in hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to better understand the characteristics and prognostic value of TMB and PD-1\/PD-L1 in hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This real-world study was conducted among patients with hematologic malignancies who had next-generation sequencing (NGS) (Foundation Medicine) at the University of California San Diego Moores Cancer Center (2014\u20132018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>TMB was measured by NGS. PD-L1 expression (tumor proportion score, TPS) was measured by immunohistochemistry (classified as high (\u2a7e50%), low (1\u201349%), and negative (&lt;1%)). Data was curated from the electronic medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In 388 evaluable patients, the most common diagnoses were B-cell non-Hodgkin lymphoma (NHL) (35%) and Philadelphia chromosome-negative myeloproliferative disorders (16%). Median TMB was 1.6\u2009mutations\/Mb (range, 0\u201346.83). Forty-eight patients (12%) had TMB \u2a7e10\u2009mutations\/Mb, 90% of which were B-cell or T-cell NHL. In 85 samples with available PD-L1 scores, 11 were high; 26, low; and 48, no tumor cell expression. PD-L1 TPS positive (\u2a7e1%) was most common in T-cell NHL (7\/9 (77%) cases) followed by B-cell NHL (21\/51 (41%) cases). TMB \u2a7e4\u2009mutations\/Mb and PD-L1 score \u2a7e1% were significantly associated with shorter overall survival (OS) from diagnosis, with hazard ratio (HR)\u2009=\u20091.46 ( p\u2009=\u20090.02, 95% confidence interval (CI) 1.05\u20132.03) and HR\u2009=\u20092.11 ( p\u2009=\u20090.04, 95% CI 1.04\u20134.30), respectively; the relationship was more pronounced when PD-L1 \u2a7e50% versus &lt;50% was used (HR\u2009=\u20092.80, p\u2009=\u20090.02, 95% CI 1.19\u20136.59). Higher TMB and higher PD-L1 positivity correlation were significant but weak (Pearson correlation coefficient R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.04, p\u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TMB \u2a7e4\u2009mutations\/Mb and positive PD-L1 TPS are poor prognostic factors, correlating with shorter OS across hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov NCT02478931.<\/jats:p>\n                  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