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In this setting, traditional chemotherapy showed limited effectiveness. In this context, antibody\u2013drug conjugates (ADCs) emerged as a promising tool within targeted cancer therapies. Tisotumab vedotin (TV), an ADC targeting tissue factor, represents the first ADC approved by the US Food and Drug Administration for the treatment of recurrent or metastatic CC with disease progression on or after chemotherapy. In phase I\u2013III published trials, TV has already demonstrated an advantage in terms of objective response rate (17.8%\u201354.4%) and progression-free survival (3.1\u20136.9 months) in patients who progressed to the first-line standard therapy. Data concerning the addition of TV to platinum\/pembrolizumab first-line chemotherapy are still under analysis and strongly expected. However, several questions are still unresolved: (1) the identification of the most suitable timing for ADCs administration in the treatment sequence of advanced\/recurrent CC; (2) the evaluation of combination therapies as a tool to minimize the emergence of resistant clones and to enhance overall effectiveness; and (3) the assessment of tolerability and correct management of special toxicities (e.g. ocular and neurological adverse events). In the near future, an improvement in patient selection via biomarker-driven strategies should be crucial for optimizing both treatment benefits and maintaining an acceptable toxicity profile.<\/jats:p>","DOI":"10.1177\/17588359241277647","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T17:12:32Z","timestamp":1727111552000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Antibody drug conjugates in recurrent or metastatic cervical cancer: a focus on tisotumab vedotin state of art"],"prefix":"10.1177","volume":"16","author":[{"given":"Floriana","family":"Camarda","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Sciences and Public Health, UOC Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariachiara","family":"Paderno","sequence":"additional","affiliation":[{"name":"Operative Unit of Gynecologic Oncology, Humanitas San Pio X, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Sciences and Public Health, UOC Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Nero","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Sciences and Public Health, UOC Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Catholic University of the Sacred Heart-Campus of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Sabatucci","sequence":"additional","affiliation":[{"name":"Operative Unit of Gynecologic Oncology, Humanitas San Pio X, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Fuc\u00e0","sequence":"additional","affiliation":[{"name":"Operative Unit of Gynecologic Oncology, Humanitas San Pio X, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Musacchio","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Sciences and Public Health, UOC Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Salutari","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Sciences and Public Health, UOC Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Sciences and Public Health, UOC Gynecologic Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Catholic University of the Sacred Heart-Campus of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-0598","authenticated-orcid":false,"given":"Domenica","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Humanitas University, Milan, Italy"},{"name":"Operative Unit of Gynecologic Oncology, Humanitas San Pio X, Via Francesco Nava, 31, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"key":"bibr1-17588359241277647","unstructured":"World Health Organization. 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