{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:54:09Z","timestamp":1790985249482,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ascites is common in advanced gastrointestinal cancers with peritoneal metastases (PM) and negatively impacts patient survival. No study to date has specifically evaluated the relationship between ascites, PM and survival outcomes in metastatic colorectal cancer (mCRC) and metastatic gastric cancer (mGC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aims to investigate and elucidate the relationship between malignant ascites, PM and survival outcomes in both mCRC and mGC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective analysis of prospectively collected clinical trial data of mCRC and mGC patients with PM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed two pooled analyses, firstly of two Italian randomized trials enrolling patients with mCRC eligible for systemic therapy (TRIBE2; VALENTINO), and secondly of gastric cancer and peritoneal metastasis (GCPM) patients who underwent bi-directional therapeutic treatment comprising systemic and peritoneal-directed therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 900 mCRC patients, 39 (4.3%) had PM with malignant ascites. Compared to the group without PM, median progression-free and overall survival were significantly inferior in the ascites group (hazard ratio (HR) for progression-free survival (PFS) 1.68, 95% confidence interval (CI): 1.21\u20132.35, p\u2009=\u20090.007; HR for overall survival (OS) 2.14, 95% CI: 1.57\u20133.01, p\u2009&lt;\u20090.001), but not in the group of PM without ascites (HR for PFS 1.10, 95% CI: 0.91 \u2013 1.34; HR for OS 1.04, 95% CI: 0.84 \u2013 1.30). Of 170 patients with GCPM, those with ascites had higher median Peritoneal Cancer Index scores (23 vs 9, p\u2009&lt;\u20090.001). Median OS was significantly inferior among those with ascites compared to those without (13.0 vs 21.0\u2009months, HR 1.71, 95% CI: 1.16\u20132.52, p\u2009=\u20090.007).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Ascites identifies a subgroup of patients with PM and poor outcomes, for whom tailored research are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359241289517","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T06:46:52Z","timestamp":1730702812000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Unveiling the prognostic significance of malignant ascites in advanced gastrointestinal cancers: a marker of peritoneal carcinomatosis burden"],"prefix":"10.1177","volume":"16","author":[{"given":"Leonardo","family":"Provenzano","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Xiang","family":"Gwee","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2013Oncology, National University Cancer Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Conca","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lonardi","sequence":"additional","affiliation":[{"name":"Medical Oncology 3 Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bozzarelli","sequence":"additional","affiliation":[{"name":"Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Tamburini","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Cardinale G. Panico Hospital, Tricase, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-240X","authenticated-orcid":false,"given":"Alessandro","family":"Passardi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u2018Dino Amadori\u2019, Meldola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zaniboni","sequence":"additional","affiliation":[{"name":"Unity of Oncology, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Tosi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Molecular Oncology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Aprile","sequence":"additional","affiliation":[{"name":"Department of Oncology, San Bortolo General Hospital, Azienda ULSS8, Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Nasca","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Boccaccino","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6943-2897","authenticated-orcid":false,"given":"Guglielmo","family":"Vetere","sequence":"additional","affiliation":[{"name":"Unity of Oncology, University Hospital of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Carullo","sequence":"additional","affiliation":[{"name":"Unity of Oncology, University Hospital of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Guaglio","sequence":"additional","affiliation":[{"name":"Colorectal Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Colorectal Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Jonathan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2013Oncology, National University Cancer Institute, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl Kai Ann","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Peng","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2013Oncology, National University Cancer Institute, Singapore, Singapore"},{"name":"Singapore Gastric Cancer Consortium, Singapore, Singapore"},{"name":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore Gastric Cancer Consortium, Singapore, Singapore"},{"name":"Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore"},{"name":"Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore"},{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore"},{"name":"SingHealth\/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"So","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore"},{"name":"Singapore Gastric Cancer Consortium, Singapore, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"Division of Surgical Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore"},{"name":"Division of Surgical Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore"},{"name":"Division of Surgical Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Ann Johnny","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Casella","sequence":"additional","affiliation":[{"name":"Upper GI Surgery Unit, Verona University Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-4841","authenticated-orcid":false,"given":"Chiara","family":"Cremolini","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy"},{"name":"Unity of Oncology, University Hospital of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bencivenga","sequence":"additional","affiliation":[{"name":"The N.1 Institute for Health, National University of Singapore, Singapore, Singapore"},{"name":"Department of Surgery, Dentistry, Pediatrics and Gynaecology, Upper GI Surgery Unit, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-1368","authenticated-orcid":false,"given":"Raghav","family":"Sundar","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2013Oncology, National University Cancer Institute, 1E Kent Ridge Road, Singapore 119228, Singapore"},{"name":"Singapore Gastric Cancer Consortium, Singapore, Singapore"},{"name":"Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore"},{"name":"The N.1 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